{"doi":"10.3389/fphys.2024.1412956","title":"Editorial: Rising stars in chronobiology 2022","abstract":"Chronobiology is the study of biological rhythms. The majority of studies in chronobiology to date have largely focused on circadian or 24-hour rhythms, but there have been increasing interests in non-circadian biological rhythms, including seasonal rhythms (Wood and Loudon 2014;Liams et al. 2019;Rohr et al. 2019;Abrieux et al. 2020) and circatidal rhythms (Kwiatkowski et al. 2023;Lin et al. 2023). The understanding of circadian rhythm has come a long way since Jean-Jacques d'Ortous de Mairan's 1729 observations that the daily rhythm of leaf movement in Mimosa pudica plants persisted even when plants were placed in the dark (de Mairan 1729). His observations provided the first evidence to support the endogenous nature of circadian rhythms. Early evidence illustrating the genetic basis of circadian rhythm were documented centuries later when Bünning showed that crosses of Phaseolus bean plants with different period lengths with regard to leaf movement produced hybrid plants with intermediate period lengths, suggesting that circadian period length of leaf movement is an inherited trait (Bünning 1932). An excellent account of the history of chronobiology has been compiled by the Society for Research on Biological Rhythms (SRBR) (https://srbr.org/about-chronobiology/chronohistory/). The scope of circadian biology is immense and the impact of circadian rhythm is pervasive. Despite all the advances in the field in the past century, there is still much to discover. Given organisms from all domains of life inhabiting a range of ecological niche are found to possess circadian clocks, and cutting-edge genomic editing tools and high throughput genomic technologies now enable researchers to study rhythms in non-model species in more natural conditions, there are now increasing opportunities to study circadian rhythms that are unique and critical to understanding species-specific biology, e.g. swarming behavior in mosquitoes (Wang et al. 2021), social entrainment in colony insects (Siehler et al. 2021), and activity rhythms in Cnidarians (Kanaya et al. 2019). Conversely, the use of diverse models in the field of chronobiology will enable comparative analysis and formulation of broad principles governing circadian rhythm and its adaptive nature. Finally, the impact of chronobiology on biomedical sciences is hard to ignore, especially after 2017 when pioneering chronobiologists Michael Young, Michael Rosbash, and Jeffrey Hall, were awarded the Nobel Prize in Physiology and Medicine \"for their discoveries of molecular mechanisms controlling the circadian rhythm\".In addition to established links between circadian disruption and many human diseases In Verlande et al. (2022), Selma Masri and her group, who are at the forefront of circadian and cancer biology, demonstrated that a stable isotope 13 C-glucose tracer, once injected in animals, can be monitored in real-time in exhaled breath to quantify glucose metabolism. They further validated this approach in models of diet-induced obesity and lung tumor progression, in which metabolic dysregulation is expected. Given circadian disruption is associated with metabolic dysregulation, this stable isotope technology will be valuable for studies in chronobiology.In Wang et al. (2022), Wanhe Li collaborated with Nobel Laureate Michael Young to leverage Drosophila sleep mutants and investigate the impact of chronic sleep loss on rhythmic gene expression. They observed significant dampening in rhythmic gene expression in sleep mutants when compared to wild type flies. Interestingly, they found a subset of genes whose rhythmic gene expression was dampened in old flies and sleep mutants with chronic sleep loss, suggesting that aging may contribute to sleep loss induced disruption of circadian gene expression.In Yuan et al. (2022) As I am concluding this editorial, I would be remiss if I do not acknowledge the significant contribution of my late colleague Steve Brown to this Special Collection. I started thi","journal":"Frontiers in Physiology","year":2024,"id":497037,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9429,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":486922,"name":"Joanna C. Chiu","orcid":"0000-0001-7613-8127","position":0,"is_corresponding":true}],"reference_count":33,"raw_metadata":null,"created_at":"2026-07-19T02:09:30.779495Z","pmid":"38725565","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}