{"doi":"10.3389/fphys.2023.1054095","title":"Pacing interventions in non-responders to cardiac resynchronization therapy","abstract":"Non-responders to Cardiac Resynchronization Therapy (CRT) represent a high-risk, and difficult to treat population of heart failure patients. Studies have shown that these patients have a lower quality of life and reduced life expectancy compared to those who respond to CRT. Whilst the first-line treatment for dyssynchronous heart failure is \"conventional\" biventricular epicardial CRT, a range of novel pacing interventions have emerged as potential alternatives. This has raised the question whether these new treatments may be useful as a second-line pacing intervention for treating non-responders, or indeed, whether some patients may benefit from these as a first-line option. In this review, we will examine the current evidence for four pacing interventions in the context of treatment of conventional CRT non-responders: CRT optimization; multisite left ventricular pacing; left ventricular endocardial pacing and conduction system pacing.","journal":"Frontiers in Physiology","year":2023,"id":349057,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9528,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":713809,"name":"Mark K. Elliott","orcid":"0000-0003-2805-3043","position":1,"is_corresponding":false},{"id":715273,"name":"Vishal Mehta","orcid":"0000-0001-6140-068X","position":2,"is_corresponding":false},{"id":964445,"name":"Felicity de Vere","orcid":null,"position":3,"is_corresponding":false},{"id":638057,"name":"Marina Strocchi","orcid":"0000-0003-1312-251X","position":4,"is_corresponding":false},{"id":891998,"name":"Jonathan M. Behar","orcid":"0000-0001-6139-227X","position":5,"is_corresponding":false},{"id":328101,"name":"Steven Niederer","orcid":"0000-0002-4612-6982","position":6,"is_corresponding":false},{"id":715275,"name":"Christopher A. Rinaldi","orcid":"0000-0002-3930-1957","position":7,"is_corresponding":false},{"id":891997,"name":"Nadeev Wijesuriya","orcid":"0000-0001-7893-0708","position":0,"is_corresponding":true}],"reference_count":77,"raw_metadata":null,"created_at":"2026-07-19T01:12:14.919810Z","pmid":"36776979","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}