{"doi":"10.3389/fphys.2022.831004","title":"Cell-to-Cell Communications in Alcohol-Associated Liver Disease","abstract":"This review covers some important new aspects of the alcohol-induced communications between liver parenchymal and non-parenchymal cells leading to liver injury development. The information exchange between various cell types may promote end-stage liver disease progression and involves multiple mechanisms, such as direct cell-to-cell interactions, extracellular vesicles (EVs) or chemokines, cytokines, and growth factors contained in extracellular fluids/cell culture supernatants. Here, we highlighted the role of EVs derived from alcohol-exposed hepatocytes (HCs) in activation of non-parenchymal cells, liver macrophages (LM), and hepatic stellate cells (HSC). The review also concentrates on EV-mediated crosstalk between liver parenchymal and non-parenchymal cells in the settings of HIV- and alcohol co-exposure. In addition, we overviewed the literature on the crosstalk between cell death pathways and inflammasome activation in alcohol-activated HCs and macrophages. Furthermore, we covered highly clinically relevant studies on the role of non-inflammatory factors, sinusoidal pressure (SP), and hepatic arterialization in alcohol-induced hepatic fibrogenesis. We strongly believe that the review will disclose major mechanisms of cell-to-cell communications pertained to alcohol-induced liver injury progression and will identify therapeutically important targets, which can be used for alcohol-associated liver disease (ALD) prevention.","journal":"Frontiers in Physiology","year":2022,"id":254118,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9521,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":226039,"name":"Akiko Eguchi","orcid":"0000-0002-0555-2707","position":1,"is_corresponding":false},{"id":302637,"name":"Ariel E. Feldstein","orcid":"0000-0001-7202-3840","position":2,"is_corresponding":false},{"id":299482,"name":"Hidekazu Tsukamoto","orcid":"0000-0002-6833-2998","position":3,"is_corresponding":false},{"id":697902,"name":"Raghubendra Singh Dagur","orcid":"0000-0001-9337-149X","position":4,"is_corresponding":false},{"id":395977,"name":"Murali Ganesan","orcid":"0000-0002-2981-568X","position":5,"is_corresponding":false},{"id":725922,"name":"Moses New‐Aaron","orcid":"0000-0001-5681-1185","position":6,"is_corresponding":false},{"id":387748,"name":"Madan Kumar Arumugam","orcid":"0000-0003-0567-7857","position":7,"is_corresponding":false},{"id":269292,"name":"Srinivas Chava","orcid":null,"position":8,"is_corresponding":false},{"id":620533,"name":"Marcelle de Carvalho Ribeiro","orcid":"0000-0001-9008-0128","position":9,"is_corresponding":false},{"id":79619,"name":"Gyöngyi Szabó","orcid":"0000-0003-0836-2527","position":10,"is_corresponding":false},{"id":405079,"name":"Sebastian Mueller","orcid":"0000-0001-5655-6778","position":11,"is_corresponding":false},{"id":900641,"name":"Shijin Wang","orcid":"0000-0002-4788-0530","position":12,"is_corresponding":false},{"id":681842,"name":"Cheng Chen","orcid":"0000-0001-8024-5128","position":13,"is_corresponding":false},{"id":542303,"name":"Steven A. Weinman","orcid":"0000-0002-8744-8873","position":14,"is_corresponding":false},{"id":381663,"name":"Kusum K. Kharbanda","orcid":"0000-0001-7759-8889","position":15,"is_corresponding":false},{"id":387753,"name":"Natalia A. Osna","orcid":"0000-0001-7498-0556","position":0,"is_corresponding":true}],"reference_count":99,"raw_metadata":null,"created_at":"2026-07-19T00:25:03.918844Z","pmid":"35264978","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}