{"doi":"10.3389/fphys.2022.812968","title":"Methodology for Cross-Talk Elimination in Simultaneous Voltage and Calcium Optical Mapping Measurements With Semasbestic Wavelengths","abstract":"Most cardiac arrhythmias at the whole heart level result from alteration of cell membrane ionic channels and intracellular calcium concentration ([Ca 2+ ] i ) cycling with emerging spatiotemporal behavior through tissue-level coupling. For example, dynamically induced spatial dispersion of action potential duration, QT prolongation, and alternans are clinical markers for arrhythmia susceptibility in regular and heart-failure patients that originate due to changes of the transmembrane voltage ( V m ) and [Ca 2+ ] i . We present an optical-mapping methodology that permits simultaneous measurements of the V m - [Ca 2+ ] i signals using a single-camera without cross-talk, allowing quantitative characterization of favorable/adverse cell and tissue dynamical effects occurring from remodeling and/or drugs in heart failure. We demonstrate theoretically and experimentally in six different species the existence of a family of excitation wavelengths, we termed semasbestic, that give no change in signal for one dye, and thus can be used to record signals from another dye, guaranteeing zero cross-talk.","journal":"Frontiers in Physiology","year":2022,"id":280113,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9577,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":586006,"name":"Christopher Crowley","orcid":"0000-0002-3637-7841","position":1,"is_corresponding":false},{"id":497144,"name":"Shahriar Iravanian","orcid":"0000-0003-2132-1543","position":2,"is_corresponding":false},{"id":332035,"name":"Tae Yun Kim","orcid":"0000-0003-0605-9575","position":3,"is_corresponding":false},{"id":954158,"name":"Hee Cheol Cho","orcid":"0000-0002-6208-3417","position":4,"is_corresponding":false},{"id":317522,"name":"Flavio H. Fenton","orcid":"0000-0002-4089-8850","position":5,"is_corresponding":false},{"id":317521,"name":"Ilija Uzelac","orcid":"0000-0003-3743-5342","position":0,"is_corresponding":true}],"reference_count":70,"raw_metadata":null,"created_at":"2026-07-19T00:28:59.341002Z","pmid":"35222080","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}