{"doi":"10.3389/fphys.2021.812212","title":"Emerging Roles for Aberrant Astrocytic Calcium Signals in Parkinson’s Disease","abstract":"Astrocytes display a plethora of spontaneous Ca 2+ signals that modulate vital functions of the central nervous system (CNS). This suggests that astrocytic Ca 2+ signals also contribute to pathological processes in the CNS. In this context, the molecular mechanisms by which aberrant astrocytic Ca 2+ signals trigger dopaminergic neuron loss during Parkinson’s disease (PD) are only beginning to emerge. Here, we provide an evidence-based perspective on potential mechanisms by which aberrant astrocytic Ca 2+ signals can trigger dysfunction in three distinct compartments of the brain, viz. , neurons, microglia, and the blood brain barrier, thereby leading to PD. We envision that the coming decades will unravel novel mechanisms by which aberrant astrocytic Ca 2+ signals contribute to PD and other neurodegenerative processes in the CNS.","journal":"Frontiers in Physiology","year":2022,"id":253113,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9461,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":437987,"name":"Rahul Srinivasan","orcid":"0000-0003-0237-6602","position":1,"is_corresponding":false},{"id":437986,"name":"Eric A. Bancroft","orcid":"0000-0002-5857-7625","position":0,"is_corresponding":true}],"reference_count":96,"raw_metadata":null,"created_at":"2026-07-19T00:24:55.325369Z","pmid":"35087422","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}