{"doi":"10.3389/fphys.2021.742844","title":"Skin Sympathetic Nerve Activity and the Short-Term QT Interval Variability in Patients With Electrical Storm","abstract":"Background : Skin sympathetic nerve activity (SKNA) and QT interval variability are known to be associated with ventricular arrhythmias. However, the relationship between the two remains unclear. Objective : The aim was to test the hypothesis that SKNA bursts are associated with greater short-term variability of the QT interval (STVQT) in patients with electrical storm (ES) or coronary heart disease without arrhythmias (CHD) than in healthy volunteers (HV). Methods : We simultaneously recorded the ECG and SKNA during sinus rhythm in patients with ES ( N = 10) and CHD ( N = 8) and during cold-water pressor test in HV ( N = 12). The QT and QTc intervals were manually marked and calculated within the ECG. The STVQT was calculated and compared to episodes of SKNA burst and non-bursting activity. Results : The SKNA burst threshold for ES and HV was 1.06 ± 1.07 and 1.88 ± 1.09 μV, respectively ( p = 0.011). During SKNA baseline and burst, the QT/QTc intervals and STVQT for ES and CHD were significantly higher than those of the HV. In all subjects, SKNA bursts were associated with an increased STVQT (from 6.43 ± 2.99 to 9.40 ± 5.12 ms, p = 0.002 for ES; from 9.48 ± 4.40 to 12.8 ± 5.26 ms, p = 0.016 for CHD; and from 3.81 ± 0.73 to 4.49 ± 1.24 ms, p = 0.016 for HV). The magnitude of increased STVQT in ES (3.33 ± 3.06 ms) and CHD (3.34 ± 2.34 ms) was both higher than that of the HV (0.68 ± 0.84 ms, p = 0.047 and p = 0.020). Conclusion : Compared to non-bursting activity, SKNA bursts were associated with a larger increase in the QTc interval and STVQT in patients with heart disease than in HV.","journal":"Frontiers in Physiology","year":2021,"id":195908,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9618,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":431454,"name":"Guannan Meng","orcid":null,"position":1,"is_corresponding":false},{"id":276398,"name":"Anisiia Doytchinova","orcid":null,"position":2,"is_corresponding":false},{"id":274524,"name":"Johnson Wong","orcid":"0000-0002-5838-8453","position":3,"is_corresponding":false},{"id":739276,"name":"Susan Straka","orcid":null,"position":4,"is_corresponding":false},{"id":768506,"name":"Julie Lacy","orcid":null,"position":5,"is_corresponding":false},{"id":430677,"name":"Xiaochun Li","orcid":"0000-0002-1547-3041","position":6,"is_corresponding":false},{"id":274534,"name":"Peng‐Sheng Chen","orcid":"0000-0002-4150-5836","position":7,"is_corresponding":false},{"id":274533,"name":"Thomas H. Everett","orcid":"0000-0002-4235-3838","position":8,"is_corresponding":false},{"id":767856,"name":"Songwen Chen","orcid":"0000-0002-6492-5702","position":0,"is_corresponding":true}],"reference_count":28,"raw_metadata":null,"created_at":"2026-07-18T23:50:11.609550Z","pmid":"35002752","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}