{"doi":"10.3389/fphys.2020.00639","title":"In vivo Assessment of Supra-Cervical Fetal Membrane by MRI 3D CISS: A Preliminary Study","abstract":"In approximately 8% of term births and 33% of pre-term births, the fetal membrane ruptures before delivery. In vitro studies of fetal membranes after delivery have suggested the series of events leading to rupture, but no in vivo studies have confirmed this model. In this study, we used a three-dimensional constructive interference in steady state sequence to examine the fetal membrane at the cervical internal os zone during pregnancy. 18 pregnant women with 1 ~ 3 longitudinal MRI scans were included in this study. In 14 women, the fetal membrane appeared normal and completely intact. In 4 women, we noted several fetal membrane abnormalities including cervical funneling, chorioamniotic separation, and chorion rupture. Our data support the in vitro model that the fetal membrane ruptures according to a sequence starting with the stretch of chorion and amnion, then the separation of amnion from chorion, next the rupture of chorion, and finally the rupture of amnion ruptures. These findings hold great promise to help to develop an in vivo magnetic resonance imaging marker that predicts early fetal membrane rupture.","journal":"Frontiers in Physiology","year":2020,"id":115739,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.959,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":252268,"name":"Peinan Zhao","orcid":"0009-0006-0883-0190","position":1,"is_corresponding":false},{"id":542391,"name":"Wei Wang","orcid":"0000-0002-5038-8563","position":2,"is_corresponding":false},{"id":542392,"name":"Zhexian Sun","orcid":"0000-0003-1225-182X","position":3,"is_corresponding":false},{"id":542393,"name":"Xiao Ma","orcid":"0000-0002-9842-9045","position":4,"is_corresponding":false},{"id":542394,"name":"Hui Wang","orcid":"0000-0002-8580-6235","position":5,"is_corresponding":false},{"id":542395,"name":"Wenjie Wu","orcid":"0000-0002-1317-104X","position":6,"is_corresponding":false},{"id":542396,"name":"Zichao Wen","orcid":"0000-0002-1169-3768","position":7,"is_corresponding":false},{"id":543112,"name":"Zulfia Kisrieva-Ware","orcid":null,"position":8,"is_corresponding":false},{"id":345270,"name":"Pamela K. Woodard","orcid":"0000-0001-9012-0812","position":9,"is_corresponding":false},{"id":320892,"name":"Qing Wang","orcid":"0000-0002-1296-7097","position":10,"is_corresponding":false},{"id":439545,"name":"Robert C. McKinstry","orcid":"0000-0003-3578-4899","position":11,"is_corresponding":false},{"id":459723,"name":"Yong Wang","orcid":"0000-0003-2507-8333","position":12,"is_corresponding":false},{"id":542390,"name":"Wenxu Qi","orcid":"0000-0001-5605-5711","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":null,"created_at":"2026-07-18T23:13:40.596604Z","pmid":"32670086","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}