{"doi":"10.3389/fphy.2019.00247","title":"Applications and Challenges of Machine Learning to Enable Realistic Cellular Simulations","abstract":"In this perspective, we examine three key aspects of an end-to-end pipeline for realistic cellular simulations: reconstruction and segmentation of cellular structures; generation of cellular structures; and mesh generation, simulation, and data analysis. We highlight some of the relevant prior work in these distinct but overlapping areas, with a particular emphasis on current use of machine learning technologies, as well as on future opportunities.","journal":"Frontiers in Physics","year":2020,"id":116501,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9533,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":545298,"name":"Meagan P. Rowan","orcid":null,"position":1,"is_corresponding":false},{"id":342657,"name":"Christopher T. Lee","orcid":"0000-0002-0670-2308","position":2,"is_corresponding":false},{"id":545299,"name":"Gregory R. Johnson","orcid":null,"position":3,"is_corresponding":false},{"id":232970,"name":"Padmini Rangamani","orcid":"0000-0001-5953-4347","position":4,"is_corresponding":false},{"id":342661,"name":"Michael Holst","orcid":"0000-0002-3064-4697","position":5,"is_corresponding":false},{"id":254425,"name":"Ritvik Vasan","orcid":"0000-0002-3225-9557","position":0,"is_corresponding":true}],"reference_count":171,"raw_metadata":null,"created_at":"2026-07-18T23:13:44.286758Z","pmid":"36188416","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}