{"doi":"10.3389/fphar.2025.1588987","title":"Enhanced resistance to Listeria infection in mice surviving sepsis: the role of lipid metabolism and myeloid cell reprogramming","abstract":"Introduction: Immune resilience is the capacity of the immune system to recover from sepsis-induced organ injury and reestablish host defense. While sepsis survivors are often viewed as immunocompromised, recent studies suggest that some may acquire adaptive immune traits that enhance resistance to secondary infections. Methods: We employed a murine cecal ligation and puncture (CLP) model to study polymicrobial sepsis and subsequent immune responses. Listeria monocytogenes was used as a model intracellular pathogen to assess immune protection. We analyzed myeloid cell phenotypes using single-cell RNA sequencing and evaluated lipid metabolic changes through quantitative RT-PCR, immunohistochemistry, serum cytokine assays, and plasma lipidomics. Results: myeloid cells exhibited increased lipid droplet accumulation, accompanied by elevated serum interferon-gamma (IFN-γ) levels. Plasma lipidomics identified systemic lipid remodeling, with increased phosphatidylserine and decreased phosphatidylinositol and phosphatidylglycerol levels. Discussion: Our findings suggest that sepsis survival induces lipid metabolic reprogramming in myeloid cells, contributing to enhanced immunity against intracellular pathogens. These insights reveal potential therapeutic targets within lipid metabolic pathways to improve host defense in sepsis survivors.","journal":"Frontiers in Pharmacology","year":2025,"id":567269,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9615,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1091210,"name":"Tengfei Song","orcid":"0000-0002-6994-6609","position":1,"is_corresponding":false},{"id":1471388,"name":"Jaewoo Choi","orcid":"0000-0002-4673-0477","position":2,"is_corresponding":false},{"id":1471389,"name":"Moses Lee","orcid":"0000-0003-1337-1065","position":3,"is_corresponding":false},{"id":329281,"name":"Kwangmin Choi","orcid":"0000-0003-4671-962X","position":4,"is_corresponding":false},{"id":1471390,"name":"Junhwan Kim","orcid":"0000-0003-2155-5294","position":5,"is_corresponding":false},{"id":605759,"name":"Barbara Sherry","orcid":"0000-0003-3119-1463","position":6,"is_corresponding":false},{"id":285336,"name":"Betty Diamond","orcid":"0000-0002-3250-3804","position":7,"is_corresponding":false},{"id":744453,"name":"Yong-Rui Zou","orcid":"0000-0002-3864-8908","position":8,"is_corresponding":false},{"id":255202,"name":"Myoungsun Son","orcid":"0000-0002-0655-3859","position":9,"is_corresponding":false},{"id":664850,"name":"Haruki Watanabe","orcid":"0000-0001-7837-086X","position":0,"is_corresponding":true}],"reference_count":65,"raw_metadata":null,"created_at":"2026-07-19T02:56:44.340853Z","pmid":"40520167","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}