{"doi":"10.3389/fphar.2022.878376","title":"Editorial: The Pharmacology of Kratom and Its Alkaloids","abstract":"The Pharmacology of Kratom and Its Alkaloids Kratom (Mitragyna speciosa Korth.) is an ethnomedicinal tree native to Southeast Asia with a long history of traditional use. During the last two decades, all indicators and metrics we have accessed suggest that kratom consumption in the United States has increased. Although there are now many self-reported motivations for kratom use, the most prominent is the self-treatment of pain, which is mediated at least in part through opioid receptors as detailed in this special issue's comprehensive review of mitragynine and its diastereomers \"The Chemical and Pharmacological Properties of Mitragynine and Its Diastereomers: An Insight Review\" (Karunakaran et al.), along with new research that indicates the involvement of adrenergic and, potentially, cannabinoid receptors, as described in \"Methadone, Buprenorphine, and Clonidine Attenuate Mitragynine Withdrawal in Rats\" (Hassan et al.) and \"Mitragynine (Kratom)-Induced Cognitive Impairments in Mice Resemble 9-THC and Morphine Effects: Reversal by Cannabinoid CB1 Receptor Antagonism\" (Iman et al.). Many individuals are reporting success using kratom to reduce opioid use despite kratom's own, generally milder, withdrawal syndrome. Also in this issue, data on kratom's potential for treating other highly-prevalent substance use disorders is being examined, as shown in \"Evaluation of Kratom Opioid Derivatives as Potential Treatment Option for Alcohol Use Disorder\" (Gutridge et al.).","journal":"Frontiers in Pharmacology","year":2022,"id":302833,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.957,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":279431,"name":"Christopher R. McCurdy","orcid":"0000-0001-8695-2915","position":1,"is_corresponding":false},{"id":506207,"name":"Darshan Singh","orcid":"0000-0002-4432-2410","position":2,"is_corresponding":false},{"id":651836,"name":"Kirsten E. Smith","orcid":"0000-0002-9278-1830","position":3,"is_corresponding":false},{"id":665191,"name":"Marc T. Swogger","orcid":"0000-0002-3662-9084","position":4,"is_corresponding":false},{"id":506204,"name":"Oliver Grundmann","orcid":"0000-0003-2302-8949","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T00:32:20.348385Z","pmid":"35370662","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}