{"doi":"10.3389/fphar.2021.759468","title":"Editorial: Oxidative Stress, Antioxidants, Transcription Factors, and Assimilation of Signal Transduction Pathways in Obesity-Related Disorders","abstract":"Obesity and its comorbidities such as fatty liver disease, type II diabetes, and cardiovascular disease can cause an onset of complications, worsened by the accompanying oxidative stress and deleterious signaling mechanisms, leading to irreversible damages. For instance, long-term fat accumulation in the liver may induce oxidative stress, sterile inflammation, and ultimately fibrosis, currently considered as an irreversible event. Oxidative stress occurs with an imbalance of heightened free radicals and reduced antioxidant pool in the body. Reactive oxygen species (ROS) are free oxygen-containing molecules that quickly react with other molecules within the cell leading to tissue damage. This is particularly evident in patients with obesity and metabolic disorders. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases and the mitochondrial oxidative chain complexes generate the majority of ROS in obesity and the metabolic syndrome, and this can contribute to renal dysfunction [reviewed in (Lee and Jose)]. To combat this complication, antuioxidants are the body's natural defense against ROS. They can be part of an extensive, integrated antioxidant defense system (i.e., glutathione, bilirubin) or derived from vitamins or nutritional sources such as vegetables, fruits, nuts, and seeds. Antioxidants have been proposed as potential therapies for obesity and its associated pathologies. As part of this collection of articles, Tun et al. reviewed the role of oxidative stress and the potential therapeutic role for several antioxidants in obesity and its related comorbidities (Tun et al.).","journal":"Frontiers in Pharmacology","year":2021,"id":221545,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9605,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":315697,"name":"Barbara Wegiel","orcid":"0000-0003-0679-8765","position":1,"is_corresponding":false},{"id":295359,"name":"Terry D. Hinds","orcid":"0000-0002-7599-1529","position":2,"is_corresponding":false},{"id":295363,"name":"David E. Stec","orcid":"0000-0001-8359-4008","position":0,"is_corresponding":true}],"reference_count":10,"raw_metadata":null,"created_at":"2026-07-18T23:53:55.215284Z","pmid":"34557106","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}