{"doi":"10.3389/fphar.2021.734892","title":"Editorial: Premature Aging and Senescence in Renal Fibrosis","abstract":"Cellular senescence, defined as the irreversible cell cycle arrest, plays an important role in both development and disease. While acute senescence is important for organogenesis and proper wound healing, perpetuation of the senescent population is associated with extensive transcriptomic reprogramming. The accompanying metabolic changes and acquisition of inflammatory and secretory properties by chronically senescent cells lead to abnormal organ repair, matrix accumulation and tissue fibrosis.","journal":"Frontiers in Pharmacology","year":2021,"id":219118,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9592,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":481413,"name":"Paul J. Higgins","orcid":"0000-0001-5208-1197","position":1,"is_corresponding":false},{"id":566154,"name":"Rohan Samarakoon","orcid":"0000-0003-0890-4947","position":0,"is_corresponding":true}],"reference_count":10,"raw_metadata":null,"created_at":"2026-07-18T23:53:33.915158Z","pmid":"34381371","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}