{"doi":"10.3389/fphar.2020.00449","title":"Effects of Early and Delayed Antiretroviral Therapy on Plasma Anti-CD4 Autoreactive IgG and Its Association With CD4+ T-Cell Recovery in Acute HIV-Infected Individuals","abstract":"Background: Plasma levels of anti-CD4 autoantibodies are increased in chronically HIV-infected patients and inversely correlated with CD4+ T-cell recovery under viral-suppressive antiretroviral therapy (ART). However, it remains unknown the effect of early ART on plasma anti-CD4 autoantibody levels in acute HIV infection (AHI). Methods: In this cohort study, we evaluated the effect of early and delayed initiation of ART on plasma anti-CD4 autoantibody levels in AHI individuals (n = 90). Blood samples were collected from men who had sex with men (MSM) with acute infection, pre-ART, and 4, 24, 48, and 96 weeks after ART. Plasma levels of anti-CD4 immunoglobulin G (IgG) were measured by ELISA. Results: We found that plasma anti-CD4 IgG levels were significantly increased in AHI individuals compared with healthy controls (HCs) prior to ART. Notably, early ART decreased plasma anti-CD4 IgG to the levels similar to HCs starting at 24 weeks (W). However, delayed initiation of ART did not significantly reduce plasma anti-CD4 IgG levels in AHI individuals. Moreover, the peripheral CD4+ T-cell counts were inversely correlated with plasma anti-CD4 IgG levels in AHI individuals at 48 and 96W after early ART but not after delayed ART. Conclusions: Taken together, our findings demonstrate for the first time that early ART, but not delayed initiation of ART, is effective in influencing anti-CD4 autoantibody production and recovering CD4+ T-cell counts in AHI individuals.","journal":"Frontiers in Pharmacology","year":2020,"id":105380,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9461,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":421703,"name":"Zhen Li","orcid":"0000-0003-2771-3425","position":1,"is_corresponding":false},{"id":365575,"name":"Zhenwu Luo","orcid":null,"position":2,"is_corresponding":false},{"id":510041,"name":"Xiaofan Lu","orcid":"0000-0002-0272-0242","position":3,"is_corresponding":false},{"id":285774,"name":"Rui Wang","orcid":"0000-0003-3825-3620","position":4,"is_corresponding":false},{"id":391044,"name":"Lifeng Liu","orcid":"0000-0002-7207-4602","position":5,"is_corresponding":false},{"id":510042,"name":"Wei Xia","orcid":"0000-0001-6835-0320","position":6,"is_corresponding":false},{"id":510954,"name":"Zhuang Wan","orcid":null,"position":7,"is_corresponding":false},{"id":510043,"name":"Tong Zhang","orcid":"0000-0002-9657-5129","position":8,"is_corresponding":false},{"id":391048,"name":"Bin Su","orcid":"0000-0001-5140-0440","position":9,"is_corresponding":false},{"id":510044,"name":"Wei Jiang","orcid":"0000-0002-4078-3092","position":10,"is_corresponding":false},{"id":391046,"name":"Hao Wu","orcid":"0000-0003-3083-2345","position":11,"is_corresponding":false},{"id":510040,"name":"Aixin Song","orcid":"0000-0002-0028-5558","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":null,"created_at":"2026-07-18T23:12:17.683386Z","pmid":"32322209","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}