{"doi":"10.3389/fped.2022.974049","title":"Stability of novel urinary biomarkers used for lupus nephritis","abstract":"Background: The Renal Activity Index for Lupus (RAIL) is a composite score of six urinary biomarkers (neutrophil gelatinase-associated lipocalin (NGAL), monocyte chemoattractant protein-1 (MCP-1), kidney injury molecule-1 (KIM-1), ceruloplasmin, adiponectin, and hemopexin) used to monitor lupus nephritis activity in children. We tested stability of RAIL biomarkers prior to meaningful clinical use. Methods: Deming Regression, Bland-Altman and Spearman Correlation Coefficient. Results: Biomarker concentration were comparable to freshly collected urine following storage at -80 °C for up to 3 months, and at 4 or 25 °C up to 48 h followed by -80 °C. Neither shipping on dry or wet ice exposure nor addition of two freeze-thaw cycles led to loss of signal, with excellent Spearman Correlation coefficients under all conditions. Conclusions: RAIL biomarkers are stable following short-term storage at clinically relevant conditions.","journal":"Frontiers in Pediatrics","year":2022,"id":290270,"datarank":0.3410258473421482,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.09961016047703312,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.09961016047703312,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":3,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9541,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":903590,"name":"James Rose","orcid":null,"position":1,"is_corresponding":false},{"id":372514,"name":"Bin Huang","orcid":"0000-0001-9724-675X","position":2,"is_corresponding":false},{"id":422178,"name":"Tingting Qiu","orcid":"0000-0002-1983-8810","position":3,"is_corresponding":false},{"id":320028,"name":"Hermine I. Brunner","orcid":"0000-0001-9478-2987","position":4,"is_corresponding":false},{"id":244962,"name":"Prasad Devarajan","orcid":"0000-0002-7847-8552","position":5,"is_corresponding":false},{"id":792133,"name":"Ellen Cody","orcid":"0000-0003-4450-6743","position":0,"is_corresponding":true}],"reference_count":27,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:30:26.667578Z","pmid":"35967565","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}