{"doi":"10.3389/fped.2022.973193","title":"Treatment of latent tuberculosis in a child with mucopolysaccharidosis type I receiving enzyme replacement therapy: A case report","abstract":"<jats:p>Mucopolysaccharidosis type I S (MPS IS) is a rare autosomal recessive lysosomal storage disorder caused by mutations in the <jats:italic>IDUA</jats:italic> gene, leading to a deficiency of the enzyme alpha-L-iduronidase. Enzyme replacement therapy (ERT) reduces lysosomal storage in the liver and improves clinical manifestations. To date, there are no published reports of tuberculosis (TB) treatment in MPS IS patients receiving ERT and as such it is not known whether both conditions can be treated simultaneously. Here, we report the case of a 14-year-old male with MPS IS receiving ERT with laronidase who was diagnosed with a latent TB infection after being in contact with a multi-drug-resistant TB patient. He received prophylactic TB treatment with moxifloxacin for 6 months. No complications were reported and there has been no active TB disease. Our case report demonstrates that TB and MPS IS can be treated simultaneously without serious adverse effects.</jats:p>","journal":"Frontiers in Pediatrics","year":2022,"id":594000,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1520384,"name":"Madara Auzenbaha","orcid":null,"position":1,"is_corresponding":false},{"id":1520385,"name":"Ieva Grinfelde","orcid":null,"position":2,"is_corresponding":false},{"id":1520386,"name":"Anita Skangale","orcid":null,"position":3,"is_corresponding":false},{"id":1520383,"name":"Lauma Vasilevska","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Treatment of latent tuberculosis in a child with mucopolysaccharidosis type I receiving enzyme replacement therapy: A case report","abstract":"<jats:p>Mucopolysaccharidosis type I S (MPS IS) is a rare autosomal recessive lysosomal storage disorder caused by mutations in the <jats:italic>IDUA</jats:italic> gene, leading to a deficiency of the enzyme alpha-L-iduronidase. Enzyme replacement therapy (ERT) reduces lysosomal storage in the liver and improves clinical manifestations. To date, there are no published reports of tuberculosis (TB) treatment in MPS IS patients receiving ERT and as such it is not known whether both conditions can be treated simultaneously. Here, we report the case of a 14-year-old male with MPS IS receiving ERT with laronidase who was diagnosed with a latent TB infection after being in contact with a multi-drug-resistant TB patient. He received prophylactic TB treatment with moxifloxacin for 6 months. No complications were reported and there has been no active TB disease. Our case report demonstrates that TB and MPS IS can be treated simultaneously without serious adverse effects.</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36052356","pmcid":"PMC9424730","openalex_id":"https://openalex.org/W4291939182","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.11524614,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.frontiersin.org/articles/10.3389/fped.2022.973193/pdf","host_type":"journal"},{"url":"https://www.frontiersin.org/articles/10.3389/fped.2022.973193/pdf","host_type":"publisher"},{"url":"https://www.frontiersin.org/articles/10.3389/fped.2022.973193/full","host_type":"publisher"},{"url":"https://doi.org/10.3389/fped.2022.973193","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36052356","host_type":"repository"},{"url":"https://doaj.org/article/cf38c9f31df4419b8f4997af663ca955","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9424730","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC9424730","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC9424730?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Lysosomal Storage Disorders Research","Biomedical Research and Pathophysiology","Pancreatitis Pathology and Treatment"],"mesh_terms":[],"keywords":["Enzyme replacement therapy","Medicine","Lysosomal storage disease","Mucopolysaccharidosis","Tuberculosis","Latent tuberculosis","Mucopolysaccharidosis type I","Newborn screening","Disease","Pediatrics","Adverse effect","Substrate reduction therapy","Mucopolysaccharidosis I","Fabry disease","Surgery","Internal medicine","Mycobacterium tuberculosis","Pathology","Enzyme Replacement Therapy (Ert)","Laronidase","Latent Tuberculosis Treatment","Multi Drug Resistant Tuberculosis (Mdr-Tb)"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"omim"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-27T13:07:19.343754Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}