{"doi":"10.3389/fped.2021.675374","title":"Improvement in Health-Related Quality of Life After Community Acquired Pediatric Septic Shock","abstract":"Background: Although some pediatric sepsis survivors experience worsening health-related quality of life (HRQL), many return to their pre-illness HRQL. Whether children can improve beyond baseline is not known. We examined a cohort of pediatric sepsis survivors to determine if those with baseline HRQL scores below the population mean could exhibit ≥10% improvement and evaluated factors associated with improvement. Methods: In this secondary analysis of the Life After Pediatric Sepsis Evaluation prospective study, children aged 1 month to 18 years admitted to 12 academic PICUs in the United States with community-acquired septic shock who survived to 3 months and had baseline HRQL scores ≤ 80 (i.e., excluding those with good baseline HRQL to allow for potential improvement) were included. HRQL was measured using the Pediatric Quality of Life Inventory or Stein-Jessop Functional Status Scale. Findings: One hundred and seventeen children were eligible. Sixty-one (52%) had ≥ 10% improvement in HRQL by 3 months. Lower pre-sepsis HRQL was associated with increased odds of improvement at 3 months [aOR = 1.08, 95% CI (1.04–1.11), p < 0.001] and 12 months [OR = 1.05, 95% CI (1.02–1.11), p = 0.005]. Improvement in HRQL was most prevalent at 3 month follow-up; at 12 month follow-up, improvement was more sustained among children without severe developmental delay compared to children with severe developmental delay. Interpretation: More than half of these children with community acquired septic shock experienced at least a 10% improvement in HRQL from baseline to 3 months. Children with severe developmental delay did not sustain this improvement at 12 month follow-up.","journal":"Frontiers in Pediatrics","year":2021,"id":202721,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9652,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":343802,"name":"Robert A. Berg","orcid":"0000-0001-5529-9431","position":1,"is_corresponding":false},{"id":356445,"name":"Athena F. Zuppa","orcid":"0000-0002-8662-7474","position":2,"is_corresponding":false},{"id":467243,"name":"Christopher J. L. Newth","orcid":"0000-0002-5705-5227","position":3,"is_corresponding":false},{"id":285986,"name":"Murray M. Pollack","orcid":"0000-0003-0966-8261","position":4,"is_corresponding":false},{"id":285987,"name":"Kathleen L. Meert","orcid":"0000-0002-4903-3503","position":5,"is_corresponding":false},{"id":446153,"name":"Mark W. Hall","orcid":"0000-0002-9595-2308","position":6,"is_corresponding":false},{"id":356438,"name":"Michael W. Quasney","orcid":"0000-0002-0003-6500","position":7,"is_corresponding":false},{"id":285643,"name":"Anil Sapru","orcid":"0000-0003-1528-8249","position":8,"is_corresponding":false},{"id":34789,"name":"Joseph A. Carcillo","orcid":"0000-0001-8920-4330","position":9,"is_corresponding":false},{"id":285988,"name":"Patrick S. McQuillen","orcid":"0000-0002-8837-364X","position":10,"is_corresponding":false},{"id":242089,"name":"Peter M. Mourani","orcid":"0000-0002-1829-3775","position":11,"is_corresponding":false},{"id":287304,"name":"Ranjit S. Chima","orcid":null,"position":12,"is_corresponding":false},{"id":502580,"name":"Richard Holubkov","orcid":"0000-0003-0431-3381","position":13,"is_corresponding":false},{"id":313498,"name":"Vinay Nadkarni","orcid":"0000-0002-3794-5599","position":14,"is_corresponding":false},{"id":285985,"name":"Ron Reeder","orcid":"0000-0003-0021-5944","position":15,"is_corresponding":false},{"id":285990,"name":"Jerry J. Zimmerman","orcid":"0000-0002-6936-3139","position":16,"is_corresponding":false},{"id":783348,"name":"the Life After Pediatric Sepsis Evaluation (LAPSE) Investigators","orcid":null,"position":17,"is_corresponding":false},{"id":242099,"name":"Neethi Pinto","orcid":"0000-0002-7877-3228","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:51:10.291262Z","pmid":"34490155","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}