{"doi":"10.3389/fped.2021.601092","title":"Prenatal IgE as a Risk Factor for the Development of Childhood Neurodevelopmental Disorders","abstract":"Background: Few studies have examined if maternal allergic disease is associated with an offspring's neurodevelopment. We hypothesized that Th-2 biased maternal immune function assessed as total serum immunoglobulin (Ig) E is associated with attention deficit hyperactivity disorder (ADHD). Methods: Data are from the Wayne County Health, Environment, Allergy, and Asthma Longitudinal Study (WHEALS), a racially and socioeconomically diverse birth cohort in metropolitan Detroit, Michigan. Maternal total IgE was measured prenatally and at 1-month postpartum. Child total IgE was assessed at birth, 6 months, and 2 years of age. ADHD diagnosis was based on the parental report at the 10–12-year study visits or medical chart abstraction. Total IgE was log 2 transformed. Poisson regression models with robust error variance were used to calculate the risk ratios (RR). Inverse probability weighting was used to correct for potential bias due to a loss to follow-up and non-response. Results: Of the 636 maternal-child pairs in the analysis, 513 children were neurotypical and 123 had ADHD. Maternal prenatal total IgE was significantly associated with ADHD even after adjustment for potential confounders (RR = 1.08, 95% CI 1.03–1.13). Maternal and child IgE measures were positively and significantly correlated, but child total IgE was not associated with ADHD at any time point. Conclusions: Maternal prenatal IgE may influence neurodevelopment, but additional studies are needed to confirm and expand these findings.","journal":"Frontiers in Pediatrics","year":2021,"id":193865,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9535,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":334928,"name":"Alexandra R. Sitarik","orcid":"0000-0001-8957-389X","position":1,"is_corresponding":false},{"id":306763,"name":"Christine Cole Johnson","orcid":"0000-0002-6864-6604","position":2,"is_corresponding":false},{"id":294197,"name":"Ganesa Wegienka","orcid":"0000-0001-7281-1193","position":3,"is_corresponding":false},{"id":306767,"name":"Dennis R. Ownby","orcid":"0000-0003-0944-6466","position":4,"is_corresponding":false},{"id":763705,"name":"Tisa Johnson-Hooper","orcid":null,"position":5,"is_corresponding":false},{"id":763706,"name":"Ghassan Allo","orcid":null,"position":6,"is_corresponding":false},{"id":306768,"name":"Albert M. Levin","orcid":"0000-0002-6993-1669","position":7,"is_corresponding":false},{"id":306778,"name":"Andrea E. Cassidy‐Bushrow","orcid":"0000-0001-8272-4448","position":8,"is_corresponding":false},{"id":463363,"name":"Jennifer K. Straughen","orcid":"0000-0002-2208-524X","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":null,"created_at":"2026-07-18T23:49:55.282992Z","pmid":"34055677","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}