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In this review we offer an overview of the state of the art regarding the actual knowledge about BRCA and HRD mutational status, the rationale of PARPi use and HRD testing (current and in development assays) and their implications in clinical practice and in the treatment decision process, in order to optimize and choose the best tailored therapy in patients with ovarian cancer.</jats:p>","journal":"Frontiers in Oncology","year":2024,"id":603334,"datarank":0.5456379239589579,"base_score":3.6375861597263857,"endowment":3.6375861597263857,"self_citation_contribution":0.5456379239589579,"citation_network_contribution":0.0,"self_endowment_contribution":0.5456379239589579,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":37,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1547724,"name":"Veronica Tius","orcid":null,"position":1,"is_corresponding":false},{"id":1547726,"name":"Claudia Andreetta","orcid":null,"position":2,"is_corresponding":false},{"id":1547727,"name":"Stefano Restaino","orcid":null,"position":3,"is_corresponding":false},{"id":1547728,"name":"Anna Biasioli","orcid":null,"position":4,"is_corresponding":false},{"id":1547729,"name":"Elena Poletto","orcid":null,"position":5,"is_corresponding":false},{"id":668374,"name":"Giuseppe Damante","orcid":"0000-0003-2312-4009","position":6,"is_corresponding":false},{"id":1547730,"name":"Alfredo Ercoli","orcid":null,"position":7,"is_corresponding":false},{"id":1547731,"name":"Lorenza Driul","orcid":null,"position":8,"is_corresponding":false},{"id":686803,"name":"Anna Fagotti","orcid":"0000-0001-5579-335X","position":9,"is_corresponding":false},{"id":406831,"name":"Domenica Lorusso","orcid":"0000-0003-0981-0598","position":10,"is_corresponding":false},{"id":315599,"name":"Giovanni Scambia","orcid":"0000-0002-9503-9041","position":11,"is_corresponding":false},{"id":1547732,"name":"Giuseppe Vizzielli","orcid":null,"position":12,"is_corresponding":false},{"id":1547722,"name":"Martina Arcieri","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"How BRCA and homologous recombination deficiency change therapeutic strategies in ovarian cancer: a review of literature","abstract":"<jats:p>About 50% of High Grade Serous Ovarian Cancer exhibit a high degree of genomic instability due to mutation of genes involved in Homologous Recombination (HRD) and such defect accounts for synthetic lethality mechanism of PARP inhibitors (PARP-i). 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In this review we offer an overview of the state of the art regarding the actual knowledge about BRCA and HRD mutational status, the rationale of PARPi use and HRD testing (current and in development assays) and their implications in clinical practice and in the treatment decision process, in order to optimize and choose the best tailored therapy in patients with ovarian cancer.</jats:p>","is_dataset_classified":null,"base_score":3.6375861597263857,"endowment":3.6375861597263857,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38525421","pmcid":"PMC10957789","openalex_id":"https://openalex.org/W4392593808","authors":[],"funders":[],"total_grants":0,"fwci":6.7519,"citation_percentile":0.98053225,"influential_citations":0,"citation_trend":[{"year":2024,"count":11},{"year":2025,"count":14},{"year":2026,"count":12}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1335196/pdf","host_type":"journal"},{"url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1335196/pdf","host_type":"publisher"},{"url":"https://www.frontiersin.org/articles/10.3389/fonc.2024.1335196/full","host_type":"publisher"},{"url":"https://doi.org/10.3389/fonc.2024.1335196","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38525421","host_type":"repository"},{"url":"https://doaj.org/article/3d1bed078930434ca0103b78ab067442","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC10957789","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC10957789?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["PARP inhibition in cancer therapy","DNA Repair Mechanisms","CRISPR and Genetic Engineering"],"mesh_terms":[],"keywords":["Ovarian cancer","Homologous recombination","BRCA mutation","Medicine","PARP inhibitor","Genome instability","Oncology","Cancer","Synthetic lethality","Clinical trial","Genetic testing","Mutation","Bioinformatics","Serous fluid","Internal medicine","Poly ADP ribose polymerase","Cancer research","DNA repair","Gene","Genetics","Biology","DNA","DNA damage","Overall Survival","Parp Inhibitors","Homologous Recombination Deficiency","Brcaness","Hrd Testing","Brca Protein"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T21:38:44.626118Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}