{"doi":"10.3389/fonc.2023.1297152","title":"Editorial: Therapy resistance in tumor microenvironment: metabolic reprogramming and purinergic signaling","abstract":"Fundamental pathophysiological processes such as tissue homeostasis, neurodegeneration, immunity, 14 inflammation, and cancer are modulated by purinergic signaling (1). The tumor microenvironment 15 (TME) is enriched in nucleosides and nucleotides, and its cellular and biochemical composition affects 16 tumor progression, metastatic spread, and response to therapy (2). Current therapeutic approaches such 17 as surgery, chemotherapy, targeted therapy, hormonal therapy, radiotherapy, and immunotherapy can 18 profoundly alter TME composition, causing extensive cell death, activating the immune system, and 19 provoking a massive release of inflammatory and damage-associated molecular patterns (DAMPS), 20 including nucleotides (ATP and ADP) and nucleosides (adenosine) (3). tumor growth and immune responses in the TME. The input from these studies will be crucial, in our 86 opinion, to outline future research to define how these purinergic sensors affect antitumor immunity 87 and cancer cell homeostasis in different therapeutic contexts.","journal":"Frontiers in Oncology","year":2023,"id":413671,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9613,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":586845,"name":"Henrique Borges da Silva","orcid":"0000-0001-9424-3326","position":1,"is_corresponding":false},{"id":1194929,"name":"Elena Adinolfi","orcid":"0000-0001-8129-9929","position":2,"is_corresponding":false},{"id":644121,"name":"Michele Zanoni","orcid":"0000-0003-1826-9430","position":0,"is_corresponding":true}],"reference_count":8,"raw_metadata":null,"created_at":"2026-07-19T01:21:57.641539Z","pmid":"38023158","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}