{"doi":"10.3389/fonc.2022.852844","title":"Patient-Reported Financial Burden Following Stereotactic Body Radiation Therapy for Localized Prostate Cancer","abstract":"Introduction and Objectives: In patients with localized prostate cancer, 5-fraction, stereotactic body radiation therapy (SBRT) has been found to offer comparable oncologic outcomes and potential for improved treatment compliance compared to conventional, 40-plus fraction radiation therapy (RT). Recent studies of oncologic patient experiences have highlighted both the impact of therapy-associated financial toxicity (FT) on treatment adherence and health-related quality of life (HRQOL). Methods: A cross-sectional assessment of FT after SBRT was performed using the 12-item COST questionnaire. The total questionnaire score (range 0-44) was used to evaluate the FT grade (0-3), with a higher COST value representing lower grade. The patient zip code was used to approximate the distance from the index hospital. Univariate and multivariate analyses of the average COST score (0-4) are performed. Results: The response rate was 57.5% (332 of 575 consented patients) with 90.7%, 8.2%, and 1.1% experiencing grade 0, 1, and 2 FT, respectively, with no grade 3. Unemployment or disability, non-white race, low income, and concurrent hormonal therapy were associated with a statistically significant worse FT (lower COST value) on univariate and multivariate analyses (p < 0.05). Education level and insurance status significant were evaluated on univariate analysis only. There was a non-statistically significant difference in age, marital status, time since treatment, and distance from the index hospital. Conclusions: SBRT was associated with low FT. However, statistically significant socioeconomic disparities in FT remain despite ultra-hypofractionated treatment.","journal":"Frontiers in Oncology","year":2022,"id":272686,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9536,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":519178,"name":"Michael Creswell","orcid":"0000-0002-6978-4128","position":1,"is_corresponding":false},{"id":939238,"name":"Alexandra T. Payne","orcid":"0000-0002-7845-3697","position":2,"is_corresponding":false},{"id":939692,"name":"Michael Markel","orcid":null,"position":3,"is_corresponding":false},{"id":416476,"name":"Abigail Pepin","orcid":"0000-0002-2441-9338","position":4,"is_corresponding":false},{"id":774629,"name":"Michael Carrasquilla","orcid":"0000-0003-0957-0248","position":5,"is_corresponding":false},{"id":325662,"name":"Alan Zwart","orcid":"0000-0001-6834-9290","position":6,"is_corresponding":false},{"id":417203,"name":"Malika Danner","orcid":null,"position":7,"is_corresponding":false},{"id":417202,"name":"Marilyn Ayoob","orcid":null,"position":8,"is_corresponding":false},{"id":417204,"name":"Thomas Yung","orcid":null,"position":9,"is_corresponding":false},{"id":416478,"name":"Brian T. Collins","orcid":"0000-0003-4811-4827","position":10,"is_corresponding":false},{"id":317310,"name":"Deepak Kumar","orcid":"0000-0002-0418-5116","position":11,"is_corresponding":false},{"id":416475,"name":"Nima Aghdam","orcid":"0000-0001-8078-0438","position":12,"is_corresponding":false},{"id":417205,"name":"Simeng Suy","orcid":null,"position":13,"is_corresponding":false},{"id":519181,"name":"Ryan Hankins","orcid":"0000-0001-5586-0102","position":14,"is_corresponding":false},{"id":939239,"name":"Keith Kowalczyk","orcid":"0000-0002-3081-6815","position":15,"is_corresponding":false},{"id":16593,"name":"Sean P. Collins","orcid":"0000-0002-2305-9836","position":16,"is_corresponding":false},{"id":802679,"name":"Tamir Sholklapper","orcid":"0000-0002-2059-1966","position":0,"is_corresponding":true}],"reference_count":20,"raw_metadata":null,"created_at":"2026-07-19T00:27:47.926496Z","pmid":"35402242","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}