{"doi":"10.3389/fonc.2022.1084717","title":"Editorial: Role of pigmentation in melanoma","abstract":"Melanomas are tumors derived from melanocytes. These cells produce melanin pigment, and act as regulators of cutaneous homeostasis, which is disturbed by various stressors (Figure Melanogenesis is a multistep process that is initiated by tyrosinase-mediated oxidation of tyrosine. Under physiological conditions, melanin synthesized inside melanosomes is transferred from melanocytes to neighboring keratinocytes, creating the functional melanin unit that protects skin cells against ultraviolet-induced damages [(4), Casalou et al.; Slominski et al.]. The protective properties of melanin result from its ability to act as anti-oxidative agent, as well as to bind cations, anions, and other molecules and chemicals. However, such protective properties can be turned to the advantage of melanoma cells, while melanogenesis itself creates toxic intermediates, and pheomelanin is an unstable molecule whose photolysis generates free radicals. These undesirable conditions promote melanomagenesis as well. Pigmentation is in fact associated with worse outcome in metastatic melanoma patients (5) and increased resistance to therapy","journal":"Frontiers in Oncology","year":2022,"id":302215,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9528,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":510309,"name":"Laura Poliseno","orcid":"0000-0001-6557-955X","position":1,"is_corresponding":false},{"id":97237,"name":"Andrzej Słomiński","orcid":"0000-0001-8963-3995","position":2,"is_corresponding":false},{"id":94308,"name":"Anna A. Brożyna","orcid":"0000-0002-3195-9965","position":0,"is_corresponding":true}],"reference_count":10,"raw_metadata":null,"created_at":"2026-07-19T00:32:16.279991Z","pmid":"36505857","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}