{"doi":"10.3389/fonc.2022.1083150","title":"Digital image analysis using video microscopy of human-derived prostate cancer vs normal prostate organoids to assess migratory behavior on extracellular matrix proteins","abstract":"The advent of perpetuating living organoids derived from patient tissue is a promising avenue for cancer research but is limited by difficulties with precise characterization. In this brief communication, we demonstrate via time-lapse imaging distinct phenotypes of prostate organoids derived from patient material– without confirmation of cellular identity. We show that organoids derived from histologically normal tissue more readily spread on a physiologic extracellular matrix (ECM) than on pathologic ECM (p<0.0001), while tumor-derived organoids spread equally on either substrate (p=0.2406). This study is an important proof-of-concept to defer precise characterization of organoids and still glean information into disease pathology.","journal":"Frontiers in Oncology","year":2023,"id":378308,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9499,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":586831,"name":"Natalia A. Ignatenko","orcid":"0000-0002-8096-1340","position":1,"is_corresponding":false},{"id":1077962,"name":"Noel A. Warfel","orcid":"0000-0001-6410-9011","position":2,"is_corresponding":false},{"id":332037,"name":"Ken Batai","orcid":"0000-0002-0317-1118","position":3,"is_corresponding":false},{"id":531923,"name":"Anne E. Cress","orcid":"0000-0001-6194-0061","position":4,"is_corresponding":false},{"id":1142246,"name":"Grant R. Pollock","orcid":"0000-0002-4520-9268","position":5,"is_corresponding":false},{"id":1142247,"name":"Ava C. Wong","orcid":"0000-0003-1777-219X","position":6,"is_corresponding":false},{"id":1117479,"name":"Benjamin R. Lee","orcid":"0000-0001-6558-4551","position":7,"is_corresponding":false},{"id":938999,"name":"Kendra D. Marr","orcid":"0000-0002-2280-2368","position":0,"is_corresponding":true}],"reference_count":9,"raw_metadata":null,"created_at":"2026-07-19T01:16:44.708019Z","pmid":"36727054","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}