{"doi":"10.3389/fonc.2021.775050","title":"Integration of a Geriatric Assessment With Intervention in the Care of Older Adults With Hematologic Malignancies","abstract":"The incidence of hematologic malignancies (HMs) is highest in the seventh decade of life and coincides with increasing occult, age-related vulnerabilities. Identification of frailty is useful in prognostication and treatment decision-making for older adults with HMs. This real-world analysis describes 311 older adults with HMs evaluated in a multidisciplinary oncogeriatric clinic. The accumulation of geriatric conditions [1-unit increase, hazards ratio (HR) = 1.13, 95% CI 1.00-1.27, p = 0.04] and frailty assessed by the Rockwood Clinical Frailty Scale (CFS, mild/moderate/severe frailty vs. very fit/well, HR = 2.59, 95% CI 1.41-4.78, p = 0.002) were predictive of worse overall survival. In multivariate analysis, HM type [acute leukemia, HR = 3.84, 95% CI 1.60-9.22, p = 0.003; myelodysplastic syndrome (MDS)/myeloproliferative neoplasm (MPN)/bone marrow failure, HR = 2.65, 95% CI 1.10-6.35, p = 0.03], age (per 5-year increase, HR = 1.46, 95% CI 1.21-1.76, p < 0.001), hemoglobin (per 1 g/dl decrease, HR = 1.21, 95% CI 1.05-1.40, p = 0.009), deficit in activities of daily living (HR = 2.20, 95% CI 1.11-4.34, p = 0.02), and Mini Nutrition Assessment score (at-risk of malnutrition vs. normal, HR = 2.00, 95% CI 1.07-3.73, p = 0.03) were independently associated with risk of death. The most commonly prescribed geriatric interventions were in the domains of audiology (56%) and pharmacy (54%). The Rockwood CFS correlated with prescribed interventions in nutrition (p = 0.01) and physical function (p < 0.001) domains. Geriatric assessment with geriatric intervention can be practically integrated into the routine care of older adults with HMs.","journal":"Frontiers in Oncology","year":2021,"id":182422,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9547,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":278928,"name":"Ying Huang","orcid":"0000-0001-9910-1212","position":1,"is_corresponding":false},{"id":734733,"name":"Ashleigh Keiter","orcid":"0000-0002-0125-7663","position":2,"is_corresponding":false},{"id":735469,"name":"Allesia Funderburg","orcid":null,"position":3,"is_corresponding":false},{"id":735470,"name":"Colin Kloock","orcid":null,"position":4,"is_corresponding":false},{"id":735471,"name":"Nicholas Yuhasz","orcid":null,"position":5,"is_corresponding":false},{"id":466007,"name":"Tanya R. Gure","orcid":"0000-0001-6188-8195","position":6,"is_corresponding":false},{"id":344865,"name":"Edmund Folefac","orcid":"0000-0002-8753-2311","position":7,"is_corresponding":false},{"id":734734,"name":"Erin Stevens","orcid":"0000-0002-8876-2557","position":8,"is_corresponding":false},{"id":336037,"name":"Carolyn J. Presley","orcid":"0000-0002-2607-5639","position":9,"is_corresponding":false},{"id":734735,"name":"Nicole Williams","orcid":"0000-0002-2213-0071","position":10,"is_corresponding":false},{"id":299308,"name":"Jessica L. Krok‐Schoen","orcid":"0000-0003-2484-5887","position":11,"is_corresponding":false},{"id":521821,"name":"Michelle J. Naughton","orcid":"0000-0001-6037-1522","position":12,"is_corresponding":false},{"id":312686,"name":"Ashley Rosko","orcid":"0000-0001-5875-3214","position":13,"is_corresponding":false},{"id":344864,"name":"Sarah Wall","orcid":"0000-0002-8845-1046","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":null,"created_at":"2026-07-18T23:48:13.605421Z","pmid":"34956894","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}