{"doi":"10.3389/fonc.2021.669071","title":"Case Report: Prolonged Survival Following EGFRvIII CAR T Cell Treatment for Recurrent Glioblastoma","abstract":"Autologous chimeric antigen receptor (CAR) T cells targeted to epidermal growth factor receptor variant III (CAR T-EGFRvIII) have been developed and administered experimentally to treat patients with IDH1 wildtype recurrent glioblastoma (rGBM) (NCT02209376). We report the case of a 59-year-old patient who received a single peripheral infusion of CAR T-EGFRvIII cells and survived 36 months after disease recurrence, exceeding expected survival for recurrent glioblastoma. Post-infusion histopathologic analysis of tissue obtained during a second stage surgical resection revealed immunosuppressive adaptive changes in the tumor tissue as well as reduced EGFRvIII expression. Serial brain imaging demonstrated a significant reduction in relative cerebral blood volume (rCBV), a measure strongly associated with tumor proliferative activity, at early time points following CAR T treatment. Notably, CAR T-EGFRvIII cells persisted in her peripheral circulation during 29 months of follow-up, the longest period of CAR T persistence reported in GBM trials to date. These findings in a long-term survivor show that peripherally administered CAR T-EGFRvIII cells can persist for years in the circulation and suggest that this cell therapy approach could be optimized to achieve broader efficacy in recurrent GBM patients.","journal":"Frontiers in Oncology","year":2021,"id":152588,"datarank":0.6476232170304466,"base_score":4.31748811353631,"endowment":4.31748811353631,"self_citation_contribution":0.6476232170304466,"citation_network_contribution":0.0,"self_endowment_contribution":0.6476232170304466,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":74,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9553,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":256280,"name":"Fraser Henderson","orcid":"0000-0003-2253-7506","position":1,"is_corresponding":false},{"id":74579,"name":"MacLean P. Nasrallah","orcid":"0000-0003-4861-0898","position":2,"is_corresponding":false},{"id":227868,"name":"Suyash Mohan","orcid":"0000-0002-4025-115X","position":3,"is_corresponding":false},{"id":454916,"name":"Sumei Wang","orcid":"0000-0002-2011-4019","position":4,"is_corresponding":false},{"id":105473,"name":"Simon F. Lacey","orcid":"0000-0003-2882-1962","position":5,"is_corresponding":false},{"id":325454,"name":"J. Joseph Melenhorst","orcid":"0000-0001-7677-537X","position":6,"is_corresponding":false},{"id":286339,"name":"Arati Desai","orcid":"0000-0002-4849-4703","position":7,"is_corresponding":false},{"id":362112,"name":"John Y. K. Lee","orcid":"0000-0002-0293-7150","position":8,"is_corresponding":false},{"id":3658,"name":"Marcela V. Maus","orcid":"0000-0002-7578-0393","position":9,"is_corresponding":false},{"id":227870,"name":"Carl H. June","orcid":"0000-0003-0241-3557","position":10,"is_corresponding":false},{"id":225597,"name":"Steven Brem","orcid":"0000-0002-5803-8920","position":11,"is_corresponding":false},{"id":242810,"name":"Roddy S. O’Connor","orcid":"0000-0001-5645-4544","position":12,"is_corresponding":false},{"id":263102,"name":"Zev A. Binder","orcid":"0000-0003-1158-231X","position":13,"is_corresponding":false},{"id":90587,"name":"Donald M. O’Rourke","orcid":"0000-0002-8479-7314","position":14,"is_corresponding":false},{"id":647896,"name":"Joseph S. Durgin","orcid":"0000-0002-1114-817X","position":0,"is_corresponding":true}],"reference_count":22,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:43:34.972031Z","pmid":"34026647","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}