{"doi":"10.3389/fonc.2021.614640","title":"Impact of Radiation Dose on Postoperative Complications in Esophageal and Gastroesophageal Junction Cancers","abstract":"Introduction: The impact of radiation prescription dose on postoperative complications during standard of care trimodality therapy for operable stage II-III esophageal and gastroesophageal junction cancers has not been established. Methods: We retrospectively reviewed 82 patients with esophageal or gastroesophageal junction cancers treated between 2004 and 2016 with neoadjuvant chemoradiation followed by resection at a single institution. Post-operative complications within 30 days were reviewed and scored using the Comprehensive Complication Index (CCI). Results were compared between patients treated with <50 Gy and ≥ 50 Gy, as well as to published CROSS study neoadjuvant chemoradiation group data (41.4 Gy). Results: Twenty-nine patients were treated with <50 Gy (range 39.6–46.8 Gy) and 53 patients were treated with ≥ 50 Gy (range 50.0–52.5 Gy) delivered using IMRT/VMAT (41%), 3D-CRT (46%), or tomotherapy IMRT (12%). Complication rates and CCI scores between our <50 Gy and ≥ 50 Gy groups were not significantly different. Assuming a normal distribution of the CROSS data, there was no significant difference in CCI scores between the CROSS study neoadjuvant chemoradiation, <50 Gy, or ≥ 50 Gy groups. Rates of pulmonary complications were greater in the CROSS group (50%) than our <50 Gy (38%) or ≥ 50 Gy (30%) groups. Conclusions: In selected esophageal and gastroesophageal junction cancer patients, radiation doses ≥ 50 Gy do not appear to increase 30 day post-operative complication rates. These findings suggest that the use of definitive doses of radiotherapy (50–50.4 Gy) in the neoadjuvant setting may not increase post-operative complications.","journal":"Frontiers in Oncology","year":2021,"id":194622,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7852,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":765167,"name":"Megan Marsh","orcid":null,"position":1,"is_corresponding":false},{"id":10993,"name":"Martin D. McCarter","orcid":"0000-0001-8174-1713","position":2,"is_corresponding":false},{"id":432107,"name":"Robert A. Meguid","orcid":"0000-0003-2646-4252","position":3,"is_corresponding":false},{"id":765168,"name":"Narine Wandrey Bhardwaj","orcid":null,"position":4,"is_corresponding":false},{"id":499034,"name":"John D. Mitchell","orcid":"0000-0003-0045-2288","position":5,"is_corresponding":false},{"id":388857,"name":"Michael J. Weyant","orcid":"0000-0002-3333-3106","position":6,"is_corresponding":false},{"id":764576,"name":"Christopher D. Scott","orcid":"0000-0002-8300-3252","position":7,"is_corresponding":false},{"id":765169,"name":"Tracey E. Schefter","orcid":null,"position":8,"is_corresponding":false},{"id":764577,"name":"Priscilla K. Stumpf","orcid":"0000-0002-7965-3455","position":9,"is_corresponding":false},{"id":436510,"name":"Stephen Leong","orcid":"0000-0002-8838-8542","position":10,"is_corresponding":false},{"id":10995,"name":"Wells A. Messersmith","orcid":"0000-0003-2349-0885","position":11,"is_corresponding":false},{"id":332486,"name":"Christopher H. Lieu","orcid":"0000-0002-4852-4642","position":12,"is_corresponding":false},{"id":559294,"name":"Alexis D. Leal","orcid":"0000-0002-0652-8151","position":13,"is_corresponding":false},{"id":559293,"name":"S. Lindsey Davis","orcid":"0000-0003-3899-9481","position":14,"is_corresponding":false},{"id":532750,"name":"W. Thomas Purcell","orcid":null,"position":15,"is_corresponding":false},{"id":765170,"name":"Madeleine Kane","orcid":null,"position":16,"is_corresponding":false},{"id":332483,"name":"Sachin Wani","orcid":"0000-0002-2935-0560","position":17,"is_corresponding":false},{"id":764578,"name":"Raj J. Shah","orcid":"0000-0002-9736-4139","position":18,"is_corresponding":false},{"id":452269,"name":"Hazem Hammad","orcid":null,"position":19,"is_corresponding":false},{"id":371641,"name":"Steven A. Edmundowicz","orcid":"0000-0002-6541-3485","position":20,"is_corresponding":false},{"id":10997,"name":"Karyn A. Goodman","orcid":"0000-0002-4576-6355","position":21,"is_corresponding":false},{"id":764575,"name":"Noah Kastelowitz","orcid":"0000-0002-6087-0492","position":0,"is_corresponding":true}],"reference_count":15,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:49:59.476757Z","pmid":"33777751","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}