{"doi":"10.3389/fonc.2020.01772","title":"miR-29a-5p Regulates the Proliferation, Invasion, and Migration of Gliomas by Targeting DHRS4","abstract":"Gliomas are the most common malignant primary brain tumors in adults and exhibit a spectrum of aberrantly aggressive phenotypes. MicroRNAs (miRNAs) play a regulatory role in various cancers, including gliomas; however, their specific roles and mechanisms have not been fully investigated. Studies have indicated that miR-29a is a tumor-suppressive miRNA, but the data are limited. In this study, we investigated the role of miR-29a-5p in glioma and further explored its underlying mechanisms. On the basis of bioinformatics, dehydrogenase/reductase 4 (DHRS4) was considered a potential target of miR-29a-5p and was also found to be highly expressed in gliomas in our experiments. Moreover, with a luciferase reporter assay, DHRS4 was found to be a target gene of miR-29a-5p and to be correlated with glioma proliferation, invasion, and migration in our <i>in vivo</i> and <i>in vitro</i> experiments. Simultaneously, we observed that the knockdown of DHRS4 rescued the downregulation of glioma proliferation, invasion, and migration caused by treatment with a mir-29a-5p inhibitor. The present findings demonstrate that miR-29a-5p suppresses cell proliferation, invasion, and migration by targeting DHRS4, and DHRS4 may be a potential new oncogene and prognostic factor in gliomas.","journal":"Frontiers in Oncology","year":2020,"id":9118,"datarank":0.3958585994422889,"base_score":2.639057329615259,"endowment":2.639057329615259,"self_citation_contribution":0.3958585994422889,"citation_network_contribution":0.0,"self_endowment_contribution":0.3958585994422889,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0495,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-09-10","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":78255,"name":"Zhenhua Chen","orcid":"0000-0002-1381-0235","position":1,"is_corresponding":false},{"id":14675,"name":"Wei Zhao","orcid":"0000-0001-7388-0692","position":2,"is_corresponding":false},{"id":78256,"name":"Gang Cai","orcid":"0000-0003-3323-1932","position":3,"is_corresponding":false},{"id":78257,"name":"Zhifeng Wang","orcid":"0000-0002-1153-4337","position":4,"is_corresponding":false},{"id":78258,"name":"Xuejiang Wang","orcid":"0000-0001-6408-0458","position":5,"is_corresponding":false},{"id":78259,"name":"Hongkang Hu","orcid":null,"position":6,"is_corresponding":false},{"id":1647,"name":"Yi Zhang","orcid":"0000-0002-2789-0811","position":7,"is_corresponding":false},{"id":78254,"name":"Yong Dai","orcid":"0000-0002-6840-9158","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":null,"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}