{"doi":"10.3389/fonc.2020.01413","title":"gC1qR/HABP1/p32 Is a Potential New Therapeutic Target Against Mesothelioma","abstract":"Mesothelioma is an aggressive cancer of the serous membranes with poor prognosis despite combination therapy consisting of surgery, radiotherapy, and platinum-based chemotherapy. Targeted therapies, including immunotherapies, have reported limited success, suggesting the need for additional therapeutic targets. This study investigates a potential new therapeutic target, gC1qR/HABP1/p32 (gC1qR), which is overexpressed in all morphologic subtypes of mesothelioma. gC1qR is a complement receptor that is associated with several cellular functions, including cell proliferation and angiogenesis. In vitro and in vivo experiments were conducted to test the hypothesis that targeting gC1qR with a specific gC1qR monoclonal antibody 60.11 reduces mesothelioma tumor growth, using the biphasic mesothelioma cell line MSTO-211H (MSTO). In vitro studies demonstrate cell surface and extracellular gC1qR expression by MSTO cells, and a modest 25.3 + 1.8% (n=4) reduction in cell proliferation by the gC1qR blocking 60.11 antibody. This inhibition was specific for targeting the C1q binding domain of gC1qR at aa 76-93, as a separate monoclonal antibody 74.5.2, directed against amino acids 204-218, had no discernable effect. In vivo studies, using a murine orthotopic xenotransplant model, demonstrated an even greater reduction in MSTO tumor growth (50% inhibition) in mice treated with the 60.11 antibody compared to controls. Immunohistochemical studies of resected tumors revealed increased cellular apoptosis by caspase 3 and TUNEL staining, in 60.11 treated tumors compared to controls, as well as impaired angiogenesis by decreased CD31 staining. Taken together, these data identify gC1qR as a potential new therapeutic target against mesothelioma with both antiproliferative and antiangiogenic properties.","journal":"Frontiers in Oncology","year":2020,"id":103337,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9545,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":503390,"name":"Kenneth Stier","orcid":"0000-0003-4735-6314","position":1,"is_corresponding":false},{"id":503391,"name":"Xiaoyu Li","orcid":"0000-0002-0153-4536","position":2,"is_corresponding":false},{"id":243356,"name":"Evelyn Kandov","orcid":"0000-0001-7071-9916","position":3,"is_corresponding":false},{"id":225995,"name":"Elisa de Stanchina","orcid":"0000-0002-3873-315X","position":4,"is_corresponding":false},{"id":244695,"name":"Qing Chang","orcid":"0000-0002-8290-6687","position":5,"is_corresponding":false},{"id":504096,"name":"Yuquan Xiong","orcid":null,"position":6,"is_corresponding":false},{"id":50788,"name":"Katia Manova","orcid":"0000-0003-0915-6696","position":7,"is_corresponding":false},{"id":322141,"name":"Ning Fan","orcid":null,"position":8,"is_corresponding":false},{"id":291553,"name":"Afşar Barlas","orcid":"0000-0002-4077-0777","position":9,"is_corresponding":false},{"id":41939,"name":"Berhane Ghebrehiwet","orcid":"0000-0001-5803-6872","position":10,"is_corresponding":false},{"id":227919,"name":"Prasad S. Adusumilli","orcid":"0000-0002-1699-2046","position":11,"is_corresponding":false},{"id":218303,"name":"Ellinor I.B. Peerschke","orcid":"0000-0001-5440-472X","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-18T22:42:17.920911Z","pmid":"32903438","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}