{"doi":"10.3389/fnut.2024.1338392","title":"Changes in the consumption of isoflavones, omega-6, and omega-3 fatty acids in women with metastatic breast cancer adopting a whole-food, plant-based diet: post-hoc analysis of nutrient intake data from an 8-week randomized controlled trial","abstract":"Background Diets rich in minimally processed plant-based foods are recommended to breast cancer patients, and some may have an interest in whole-food, plant-based (WFPB) diets that avoid animal-based foods, added fats, and refined sugars. Within WFPB diets, the intakes of isoflavones, omega-6 polyunsaturated fatty acids (n-6 PUFAs), and omega-3 polyunsaturated FAs (n-3 PUFAs), which have been discussed in reference to breast cancer outcomes, have not been well characterized. Methods Women with stage IV breast cancer on stable therapy were randomized 2:1 into (1) a WFPB intervention ( N = 21) or (2) usual care ( N = 11) for 8 weeks. Three meals per day were provided. Outcomes presented here include dietary intake of isoflavones, n-3 and n-6- PUFAs, which were assessed using three-day food records at baseline and 8 weeks. Baseline and 8-week mean intake within groups were compared using the Wilcoxon signed-rank test and between control and intervention groups by a two-sample t -test. Results The WFPB intervention participants increased their daily consumption of total isoflavones from a mean of 0.8 mg/day to 14.5 mg/day ( p < 0.0001) and decreased the n-6:n-3 ratio of their diet from a mean of 9.3 to 3.7 ( p < 0.0001). Within the WFPB group, linoleic acid (n-6 PUFA) consumption decreased by a mean of 3.8 g ( p = 0.0095), from 12.8 g/day to 9.0 g/day; total n-3 PUFA consumption increased by a mean of 1.1 g ( p = 0.0005), from 1.6 g/day to 2.7 g/day. Conclusion Transitioning to a WFPB diet resulted in significantly increased isoflavone intake and decreased n-6:n-3 ratio in women with breast cancer.","journal":"Frontiers in Nutrition","year":2024,"id":446531,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9484,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1168350,"name":"Erin K. Campbell","orcid":"0000-0002-6314-1164","position":1,"is_corresponding":false},{"id":266567,"name":"Eva Culakova","orcid":"0000-0002-9852-6515","position":2,"is_corresponding":false},{"id":1045082,"name":"Lisa Blanchard","orcid":"0000-0001-8693-4936","position":3,"is_corresponding":false},{"id":1045767,"name":"Nellie Wixom","orcid":null,"position":4,"is_corresponding":false},{"id":420855,"name":"Luke J. Peppone","orcid":"0000-0002-0346-5191","position":5,"is_corresponding":false},{"id":996277,"name":"Thomas M. Campbell","orcid":"0000-0003-4449-8229","position":6,"is_corresponding":false},{"id":866486,"name":"Jean Lee","orcid":"0000-0001-5751-8503","position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":null,"created_at":"2026-07-19T02:01:54.980444Z","pmid":"38577156","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}