{"doi":"10.3389/fnut.2022.827307","title":"Association Between Egg Consumption and Dementia Risk in the EPIC-Spain Dementia Cohort","abstract":"<jats:sec><jats:title>Background</jats:title><jats:p>Current evidence suggests that egg composition might have potential neuroprotective effects. Our aim was to determine the association between egg consumption and the risk of dementia in a Mediterranean population.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This study was carried out in 3 centers from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Spain Dementia Cohort, i.e., 25,015 participants aged 30–70 years, recruited in 1992–1996, and followed up for a mean of 21.5 years.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total of 774 incident dementia cases were diagnosed and validated, of which 518 were Alzheimer's disease (AD). Data on egg consumption were estimated using a validated dietary history questionnaire at recruitment. Cox proportional hazards models, adjusted for confounders, were used in the analyses. No association was observed between egg consumption and either total dementia [hazard ratio between extreme quartiles (HR<jats:sub>Q4vs.Q1</jats:sub>: 1.05; 95% CI 0.85–1.31; <jats:italic>p</jats:italic>-trend = 0.93)] or AD (HR<jats:sub>Q4vs.Q1</jats:sub> 0.93; 95% CI 0.72–1.21; <jats:italic>p</jats:italic>-trend = 0.50) risks. After dividing the population by adherence to the relative Mediterranean diet (rMED) score, a borderline inverse association was found between egg intake and both total dementia (HR<jats:sub>Q4vs.Q1</jats:sub>: 0.52; 95% CI 0.30–0.90; <jats:italic>p</jats:italic>-trend = 0.10) and AD (HR<jats:sub>Q4vs.Q1</jats:sub>: 0.52; 95% CI 0.27–1.01; <jats:italic>p</jats:italic>-trend = 0.13) risks within participants with low adherence to rMED score. However, no association was observed in participants with medium and high adherence to rMED score.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>This prospective study suggests that egg consumption is associated with a reduced risk of dementia, and specifically of AD, in the adult population with low adherence to rMED score; whereas it has no impact in subjects with moderate and high MD adherence.</jats:p></jats:sec>","journal":"Frontiers in Nutrition","year":2022,"id":671449,"datarank":0.6913128423512056,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"self_citation_contribution":0.44166584687496613,"citation_network_contribution":0.24964699547623953,"self_endowment_contribution":0.44166584687496613,"citer_contribution":0.24964699547623953,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":18,"citers_with_citation_signal":12,"citers_with_endowment":12,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1399442,"name":"Raul Zamora-Ros","orcid":"0000-0002-6236-6804","position":1,"is_corresponding":false},{"id":1754149,"name":"Izar de Villasante","orcid":null,"position":2,"is_corresponding":false},{"id":1754150,"name":"Marta Crous-Bou","orcid":null,"position":3,"is_corresponding":false},{"id":38568,"name":"María-Dolores Chirlaque","orcid":null,"position":4,"is_corresponding":false},{"id":317199,"name":"Pilar Amiano","orcid":"0000-0003-3986-7026","position":5,"is_corresponding":false},{"id":1298668,"name":"Javier Mar","orcid":"0000-0002-9455-4869","position":6,"is_corresponding":false},{"id":121220,"name":"Aurelio Barricarte","orcid":null,"position":7,"is_corresponding":false},{"id":1754151,"name":"Eva Ardanaz","orcid":null,"position":8,"is_corresponding":false},{"id":38754,"name":"José María Huerta","orcid":"0000-0002-9637-3869","position":9,"is_corresponding":false},{"id":1754148,"name":"Hernando J. Margara-Escudero","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Association Between Egg Consumption and Dementia Risk in the EPIC-Spain Dementia Cohort","abstract":"<jats:sec><jats:title>Background</jats:title><jats:p>Current evidence suggests that egg composition might have potential neuroprotective effects. Our aim was to determine the association between egg consumption and the risk of dementia in a Mediterranean population.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This study was carried out in 3 centers from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Spain Dementia Cohort, i.e., 25,015 participants aged 30–70 years, recruited in 1992–1996, and followed up for a mean of 21.5 years.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total of 774 incident dementia cases were diagnosed and validated, of which 518 were Alzheimer's disease (AD). Data on egg consumption were estimated using a validated dietary history questionnaire at recruitment. Cox proportional hazards models, adjusted for confounders, were used in the analyses. No association was observed between egg consumption and either total dementia [hazard ratio between extreme quartiles (HR<jats:sub>Q4vs.Q1</jats:sub>: 1.05; 95% CI 0.85–1.31; <jats:italic>p</jats:italic>-trend = 0.93)] or AD (HR<jats:sub>Q4vs.Q1</jats:sub> 0.93; 95% CI 0.72–1.21; <jats:italic>p</jats:italic>-trend = 0.50) risks. After dividing the population by adherence to the relative Mediterranean diet (rMED) score, a borderline inverse association was found between egg intake and both total dementia (HR<jats:sub>Q4vs.Q1</jats:sub>: 0.52; 95% CI 0.30–0.90; <jats:italic>p</jats:italic>-trend = 0.10) and AD (HR<jats:sub>Q4vs.Q1</jats:sub>: 0.52; 95% CI 0.27–1.01; <jats:italic>p</jats:italic>-trend = 0.13) risks within participants with low adherence to rMED score. However, no association was observed in participants with medium and high adherence to rMED score.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>This prospective study suggests that egg consumption is associated with a reduced risk of dementia, and specifically of AD, in the adult population with low adherence to rMED score; whereas it has no impact in subjects with moderate and high MD adherence.</jats:p></jats:sec>","is_dataset_classified":null,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35284440","pmcid":"PMC8906465","openalex_id":"https://openalex.org/W4213114006","authors":[],"funders":[],"total_grants":0,"fwci":1.93,"citation_percentile":0.84559885,"influential_citations":0,"citation_trend":[{"year":2023,"count":1},{"year":2024,"count":4},{"year":2025,"count":5},{"year":2026,"count":8}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.frontiersin.org/articles/10.3389/fnut.2022.827307/pdf","host_type":"journal"},{"url":"https://www.frontiersin.org/articles/10.3389/fnut.2022.827307/pdf","host_type":"publisher"},{"url":"https://www.frontiersin.org/articles/10.3389/fnut.2022.827307/full","host_type":"publisher"},{"url":"https://doi.org/10.3389/fnut.2022.827307","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/35284440","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8906465","host_type":"repository"},{"url":"http://hdl.handle.net/2445/184456","host_type":"repository"},{"url":"https://doaj.org/article/6bfdfd15daaa48b8a1ae77ba193f68e5","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC8906465","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC8906465?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Nutritional Studies and Diet","Dementia and Cognitive Impairment Research","Alzheimer's disease research and treatments"],"mesh_terms":[],"keywords":["Dementia","Medicine","European Prospective Investigation into Cancer and Nutrition","Hazard ratio","Prospective cohort study","Mediterranean diet","Rotterdam Study","Proportional hazards model","Cohort","Confounding","Cohort study","Population","Lower risk","Demography","Internal medicine","Disease","Environmental health","Confidence interval","Egg","Intake","Alzheimer","Epic-spain"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T02:46:47.953815Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}