{"doi":"10.3389/fnsys.2021.771661","title":"Numerical Simulation: Fluctuation in Background Synaptic Activity Regulates Synaptic Plasticity","abstract":"<jats:p>Synaptic plasticity is vital for learning and memory in the brain. It consists of long-term potentiation (LTP) and long-term depression (LTD). Spike frequency is one of the major components of synaptic plasticity in the brain, a noisy environment. Recently, we mathematically analyzed the frequency-dependent synaptic plasticity (FDP) <jats:italic>in vivo</jats:italic> and found that LTP is more likely to occur with an increase in the frequency of background synaptic activity. Meanwhile, previous studies suggest statistical fluctuation in the amplitude of background synaptic activity. Little is understood, however, about its contribution to synaptic plasticity. To address this issue, we performed numerical simulations of a calcium-based synapse model. Then, we found attenuation of the tendency to become LTD due to an increase in the fluctuation of background synaptic activity, leading to an enhancement of synaptic weight. Our result suggests that the fluctuation affects synaptic plasticity in the brain.</jats:p>","journal":"Frontiers in Systems Neuroscience","year":2021,"id":41904,"datarank":0.10638179120863783,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0024097141246460264,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0024097141246460264,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":1,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":201251,"name":"Katsuhiko Hata","orcid":null,"position":1,"is_corresponding":false},{"id":201252,"name":"Tokio Yamazaki","orcid":null,"position":2,"is_corresponding":false},{"id":201253,"name":"Masaki Kaneko","orcid":null,"position":3,"is_corresponding":false},{"id":201254,"name":"Osamu Yokoi","orcid":null,"position":4,"is_corresponding":false},{"id":201255,"name":"Chengta Tsai","orcid":null,"position":5,"is_corresponding":false},{"id":201256,"name":"Kazuo Umemura","orcid":null,"position":6,"is_corresponding":false},{"id":201257,"name":"Tetsuro Nikuni","orcid":null,"position":7,"is_corresponding":false},{"id":201250,"name":"Yuto Takeda","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34880734","pmcid":"PMC8646040","openalex_id":"https://openalex.org/W3216180119","authors":[],"funders":[{"funder_name":"Japan Society for the Promotion of Science","grant_id":"21H03327","title":null},{"funder_name":"Japan Society for the Promotion of Science","grant_id":"JP18K10858","title":null}],"total_grants":2,"fwci":0.0,"citation_percentile":0.14093009,"influential_citations":0,"citation_trend":[{"year":2025,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.frontiersin.org/articles/10.3389/fnsys.2021.771661/pdf","host_type":"journal"},{"url":"https://doi.org/10.3389/fnsys.2021.771661","host_type":"GOLD"},{"url":"https://www.frontiersin.org/articles/10.3389/fnsys.2021.771661/pdf","host_type":"publisher"},{"url":"https://www.frontiersin.org/articles/10.3389/fnsys.2021.771661/full","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34880734","host_type":"repository"},{"url":"https://doaj.org/article/da73ef2b7e35457fae87f482f74df71d","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8646040","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC8646040","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC8646040?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Neuroscience and Neuropharmacology Research","Advanced Memory and Neural Computing","Neural dynamics and brain function","Medicine","Biology","Computer Science"],"mesh_terms":[],"keywords":["Synaptic plasticity","Synaptic augmentation","Synaptic scaling","Metaplasticity","Nonsynaptic plasticity","Synaptic fatigue","Neuroscience","Long-term potentiation","Homosynaptic plasticity","Neural facilitation","Plasticity","Synapse","Homeostatic plasticity","Psychology","Biology","Physics","Excitatory postsynaptic potential","Inhibitory postsynaptic potential","fluctuation","Neural Noise","Background Synaptic Activity","Calcium-Based Model","Frequency-Dependent Synaptic Plasticity"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-13T14:05:34.592655Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}