{"doi":"10.3389/fnint.2022.840249","title":"Preventive Supplementation of Omega-3 Reduces Pain and Pro-inflammatory Cytokines in a Mouse Model of Complex Regional Pain Syndrome Type I","abstract":"Complex regional pain syndrome type I (CRPS-I) is a condition that responds poorly to treatments. The role of omega-3 fatty acids in the treatment of inflammatory disorders is well described in the literature; however, few studies have evaluated its therapeutic benefits in different types of pain. We evaluated the potential antihyperalgesic and anti-inflammatory effects of preventive omega-3 supplementation in an animal model of CRPS-I. In experiment 1, Swiss female mice were supplemented for 30 days with omega-3 before the induction of the CRPS-I model and 14 days after. Mechanical hyperalgesia was evaluated at baseline and from the 4th to the 14th day after CPRS-I induction along with open field locomotor activity after 30 days of supplementation. In experiment 2, Swiss female mice were supplemented for 30 days with omega-3 and then subjected to the CRPS-I model. Twenty-four hours later the animals were euthanized, and tissue samples of the spinal cord and right posterior paw muscle were taken to measure pro-inflammatory cytokine TNF and IL-1β concentrations. Omega-3 supplementation produced antihyperalgesic and anti-inflammatory effects, as well as reducing pro-inflammatory cytokine concentrations, without altering the animals' locomotion. No open field locomotor changes were found. The 30-day supplementation at the tested dose was effective in the CRPS-I model.","journal":"Frontiers in Integrative Neuroscience","year":2022,"id":281250,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9481,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":956490,"name":"Paula Franson Fernandes","orcid":null,"position":1,"is_corresponding":false},{"id":956100,"name":"Afonso Shiguemi Inoue Salgado","orcid":"0000-0002-5033-8777","position":2,"is_corresponding":false},{"id":956101,"name":"Francisco José Cidral‐Filho","orcid":"0000-0003-4060-5947","position":3,"is_corresponding":false},{"id":956102,"name":"Anna Paula Piovezan","orcid":"0000-0001-8817-3552","position":4,"is_corresponding":false},{"id":956491,"name":"Daniela Dero Lüdtke","orcid":null,"position":5,"is_corresponding":false},{"id":956103,"name":"Josiel Mileno Mack","orcid":"0000-0001-9993-0774","position":6,"is_corresponding":false},{"id":330736,"name":"Kenneth A. Weber","orcid":"0000-0002-0916-9174","position":7,"is_corresponding":false},{"id":348847,"name":"William Reed","orcid":"0000-0002-4580-485X","position":8,"is_corresponding":false},{"id":956104,"name":"Franciane Bobinski","orcid":"0000-0002-3537-1712","position":9,"is_corresponding":false},{"id":348846,"name":"Daniel Fernandes Martins","orcid":"0000-0003-1484-3167","position":10,"is_corresponding":false},{"id":956099,"name":"Taynah de Oliveira Galassi","orcid":"0009-0007-8793-4664","position":0,"is_corresponding":true}],"reference_count":37,"raw_metadata":null,"created_at":"2026-07-19T00:29:07.472902Z","pmid":"35431823","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}