{"doi":"10.3389/fneur.2025.1643514","title":"Ethnic disparities in patients with early-onset Alzheimer’s disease (EOAD)","abstract":"Introduction: Ethnic disparities in Early-onset Alzheimer's Disease (EOAD) have not been fully characterized. Methods: We retrospectively identified 81 EOAD patients February 2017-February 2022. Results: 53 (65.4%) identified as White and 28 (34.6%) identified as Black. Age at diagnosis (years) was (57.3 ± 5.24) in Black patients compared to (56.3 ± 4.96) in White patients. Time to diagnosis (years) was longer in Black patients (3.39 ± 1.85) compared with White patients (2.64 ± 1.75). Black patients had lower MOCA scores (12.17 ± 6.9) compared with White patients (14.9 ± 5.8). An amnestic profile was more common in Black patients (19 or 67.9%) than non-amnestic presentations (9 or 32.1%). Non-amnestic presentations were more common in White patients, with 9 (17%) patients with PCA, 8 (15%) with fAD and 8 (15%) with l-PPA. Discussion: In our cohort, Black patients with EOAD are on average older, more advanced and experienced longer delays in diagnosis than their White counterparts.","journal":"Frontiers in Neurology","year":2025,"id":586270,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.5767,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1500802,"name":"Suemin Jasmine Yoon","orcid":null,"position":1,"is_corresponding":false},{"id":1500803,"name":"Kristen Taruc","orcid":null,"position":2,"is_corresponding":false},{"id":1500804,"name":"Phyllis Timpo","orcid":null,"position":3,"is_corresponding":false},{"id":1500805,"name":"James Mastrianni","orcid":null,"position":4,"is_corresponding":false},{"id":950042,"name":"Kaitlin Seibert","orcid":"0000-0002-5400-1477","position":5,"is_corresponding":false},{"id":923038,"name":"Meredith Yang","orcid":null,"position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:59:28.666390Z","pmid":"41451410","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}