{"doi":"10.3389/fneur.2024.1482917","title":"Overlapping conditions in Long COVID at a multisite academic center","abstract":"Background Many patients experience persistent symptoms after COVID-19, a syndrome referred to as Long COVID (LC). The goal of this study was to identify novel new or worsening comorbidities self-reported in patients with LC. Methods Patients diagnosed with LC ( n = 732) at the Mayo Long COVID Care Clinic in Rochester, Minnesota and Jacksonville, Florida were sent questionnaires to assess the development of new or worsening comorbidities following COVID-19 compared to patients with SARS-CoV-2 that did not develop LC (controls). Both groups were also asked questions screening for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), generalized joint hypermobility (GJH) and orthostatic intolerance. 247 people with LC (33.7%) and 40 controls (50%) responded to the surveys. Results In this study LC patients averaged 53 years of age and were predominantly White (95%) women (75%). The greatest prevalence of new or worsening comorbidities following SARS-CoV-2 infection in patients with LC vs. controls reported in this study were pain (94.4% vs. 0%, p < 0.001), neurological (92.4% vs. 15.4%, p < 0.001), sleep (82.8% vs. 5.3%, p < 0.001), skin (69.8% vs. 0%, p < 0.001), and genitourinary (60.6% vs. 25.0%, p = 0.029) issues. 58% of LC patients screened positive for ME/CFS vs. 0% of controls ( p < 0.001), 27% positive for GJH compared to 10% of controls ( p = 0.026), and a positive average score of 4.0 on orthostatic intolerance vs. 0 ( p < 0.001). The majority of LC patients with ME/CFS were women (77%). Conclusion We found that comorbidities across 12 surveyed categories were increased in patients following SARS-CoV-2 infection. Our data also support the overlap of LC with ME/CFS, GJH, and orthostatic intolerance. We discuss the pathophysiologic, research, and clinical implications of identifying these conditions with LC.","journal":"Frontiers in Neurology","year":2024,"id":456698,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8843,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":748157,"name":"Daniel V. Dudenkov","orcid":"0000-0003-1804-3159","position":1,"is_corresponding":false},{"id":1282033,"name":"Beth Pollack","orcid":null,"position":2,"is_corresponding":false},{"id":248042,"name":"DeLisa Fairweather","orcid":"0000-0003-3093-1810","position":3,"is_corresponding":false},{"id":1282034,"name":"Chris A. Aakre","orcid":null,"position":4,"is_corresponding":false},{"id":895846,"name":"Bala Munipalli","orcid":null,"position":5,"is_corresponding":false},{"id":465434,"name":"Ivana T. Croghan","orcid":"0000-0003-3464-3525","position":6,"is_corresponding":false},{"id":1247365,"name":"Michael Mueller","orcid":"0000-0003-2415-703X","position":7,"is_corresponding":false},{"id":1282035,"name":"Joshua Overgaard","orcid":null,"position":8,"is_corresponding":false},{"id":40577,"name":"Katelyn A. Bruno","orcid":"0000-0001-8980-6059","position":9,"is_corresponding":false},{"id":1281546,"name":"Nerissa M. Collins","orcid":"0000-0002-0416-9650","position":10,"is_corresponding":false},{"id":1281547,"name":"Zhuo Li","orcid":"0000-0002-5911-8893","position":11,"is_corresponding":false},{"id":300888,"name":"Ryan T. Hurt","orcid":"0000-0003-1158-7559","position":12,"is_corresponding":false},{"id":351610,"name":"Michal Caspi Tal","orcid":"0000-0003-2550-6246","position":13,"is_corresponding":false},{"id":705343,"name":"Ravindra Ganesh","orcid":"0000-0002-6877-1712","position":14,"is_corresponding":false},{"id":895405,"name":"Dacre Knight","orcid":"0000-0001-6206-0680","position":15,"is_corresponding":false},{"id":1229656,"name":"Stephanie L. Grach","orcid":"0000-0002-8337-6219","position":0,"is_corresponding":true}],"reference_count":169,"raw_metadata":null,"created_at":"2026-07-19T02:03:32.516678Z","pmid":"39524912","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}