{"doi":"10.3389/fncel.2024.1321682","title":"Characterization of hyperpolarization-activated cyclic nucleotide-gated channels in oligodendrocytes","abstract":"Mature oligodendrocytes (OLG) are the myelin-forming cells of the central nervous system. Recent work has shown a dynamic role for these cells in the plasticity of neural circuits, leading to a renewed interest in voltage-sensitive currents in OLG. Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels and their respective current (I h ) were recently identified in mature OLG and shown to play a role in regulating myelin length. Here we provide a biochemical and electrophysiological characterization of HCN channels in cells of the oligodendrocyte lineage. We observed that mice with a nonsense mutation in the Hcn2 gene ( Hcn2 ap/ap ) have less white matter than their wild type counterparts with fewer OLG and fewer oligodendrocyte progenitor cells (OPCs). Hcn2 ap/ap mice have severe motor impairments, although these deficits were not observed in mice with HCN2 conditionally eliminated only in oligodendrocytes ( Cnp cre /+ ; Hcn2 F/F ). However, Cnp cre /+ ; Hcn2 F/F mice develop motor impairments more rapidly in response to experimental autoimmune encephalomyelitis (EAE). We conclude that HCN2 channels in OLG may play a role in regulating metabolism.","journal":"Frontiers in Cellular Neuroscience","year":2024,"id":478455,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9561,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":499263,"name":"Ye Han","orcid":"0000-0003-4687-7193","position":1,"is_corresponding":false},{"id":303802,"name":"Andrew P. Robinson","orcid":"0000-0002-1867-5634","position":2,"is_corresponding":false},{"id":230870,"name":"Samuel E. Weinberg","orcid":"0000-0002-9532-7051","position":3,"is_corresponding":false},{"id":648093,"name":"Daniel Fisher","orcid":"0000-0003-3271-8327","position":4,"is_corresponding":false},{"id":1208753,"name":"Robert J. Heuermann","orcid":"0000-0003-4884-9604","position":5,"is_corresponding":false},{"id":1317587,"name":"Reagan E. Lyman","orcid":null,"position":6,"is_corresponding":false},{"id":732779,"name":"Dong‐Kyu Kim","orcid":"0000-0003-4917-0177","position":7,"is_corresponding":false},{"id":9492,"name":"A. Ludwig","orcid":"0000-0002-1548-4621","position":8,"is_corresponding":false},{"id":104272,"name":"Navdeep S. Chandel","orcid":"0000-0001-7208-3886","position":9,"is_corresponding":false},{"id":402064,"name":"Mark D. Does","orcid":"0000-0003-2701-6208","position":10,"is_corresponding":false},{"id":242015,"name":"Stephen D. Miller","orcid":"0000-0002-9556-0718","position":11,"is_corresponding":false},{"id":499266,"name":"Dane M. Chetkovich","orcid":"0000-0001-5993-2118","position":12,"is_corresponding":false},{"id":499264,"name":"Kyle A. Lyman","orcid":"0000-0002-3309-7211","position":0,"is_corresponding":true}],"reference_count":56,"raw_metadata":null,"created_at":"2026-07-19T02:06:46.330532Z","pmid":"38469353","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}