{"doi":"10.3389/fncel.2020.00239","title":"The CNS Myelin Proteome: Deep Profile and Persistence After Post-mortem Delay","abstract":null,"journal":"Frontiers in Cellular Neuroscience","year":2020,"id":687128,"datarank":0.6892679775201885,"base_score":4.59511985013459,"endowment":4.59511985013459,"self_citation_contribution":0.6892679775201885,"citation_network_contribution":0.0,"self_endowment_contribution":0.6892679775201885,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":98,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1665324,"name":"Sophie B. 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The relative abundance of myelin proteins displays a dynamic range of over four orders of magnitude, implying that PLP and MBP have overshadowed less abundant myelin constituents in initial gel-based approaches. By comparisons with published datasets we evaluate to which degree the CNS myelin proteome correlates with the mRNA and protein abundance profiles of myelin and oligodendrocytes. Notably, the myelin proteome displays only minor changes if assessed after a post-mortem delay of 6 h. These data provide the most comprehensive proteome resource of CNS myelin so far and a basis for addressing proteomic heterogeneity of myelin in mouse models and human patients with white matter disorders.","is_dataset_classified":null,"base_score":4.59511985013459,"endowment":4.59511985013459,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"32973451","pmcid":"PMC7466725","openalex_id":"https://openalex.org/W3066361405","authors":[],"funders":[{"funder_name":"European Commission","grant_id":"647168","title":"Cell biology of myelin wrapping, plasticity and turnover"}],"total_grants":1,"fwci":4.0244,"citation_percentile":0.95313042,"influential_citations":0,"citation_trend":[{"year":2020,"count":2},{"year":2021,"count":11},{"year":2022,"count":27},{"year":2023,"count":14},{"year":2024,"count":20},{"year":2025,"count":14},{"year":2026,"count":9}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.frontiersin.org/articles/10.3389/fncel.2020.00239/pdf","host_type":"journal"},{"url":"https://www.frontiersin.org/articles/10.3389/fncel.2020.00239/pdf","host_type":"publisher"},{"url":"https://www.frontiersin.org/article/10.3389/fncel.2020.00239/full","host_type":"publisher"},{"url":"https://doi.org/10.3389/fncel.2020.00239","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/32973451","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7466725","host_type":"repository"},{"url":"https://doaj.org/article/9e4bb15b59994bdc93169cdc880d2e6c","host_type":"repository"},{"url":"https://resolver.sub.uni-goettingen.de/purl?gro-2/84386","host_type":"repository"},{"url":"http://hdl.handle.net/21.11116/0000-0007-1208-C","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC7466725","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC7466725?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.3389/fncel.2020.00239","host_type":""},{"url":"https://dx.doi.org/10.3389/fncel.2020.00239","host_type":""},{"url":"https://hdl.handle.net/21.11116/0000-0007-1208-C","host_type":""},{"url":"https://hdl.handle.net/21.11116/0000-000A-CCDA-B","host_type":""}],"fields_of_study":["RNA Research and Splicing","Neurogenesis and neuroplasticity mechanisms","RNA regulation and disease","0301 basic medicine","03 medical and health sciences"],"mesh_terms":[],"keywords":["Myelin","Proteome","Multiple sclerosis","Proteomics","Biology","Myelin basic protein","White matter","Proteolipid protein 1","Cell biology","Biochemistry","Immunology","Neuroscience","Central nervous system","Medicine","Gene","Central nervous system (CNS)","Autopsy","demyelination","Transcriptome","oligodendrocyte","Label-free Proteomics","Post-mortem Delay","Myelin Proteome","Neurosciences. Biological psychiatry. Neuropsychiatry","RC321-571"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"geo"},{"name":"omim"},{"name":"pxd"},{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T21:21:53.901847Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}