{"doi":"10.3389/fncel.2014.00427","title":"The γ-secretase complex: from structure to function","abstract":null,"journal":"Frontiers in Cellular Neuroscience","year":2014,"id":592635,"datarank":4.315416337626161,"base_score":5.049856007249537,"endowment":5.049856007249537,"self_citation_contribution":0.7574784010874307,"citation_network_contribution":3.5579379365387296,"self_endowment_contribution":0.7574784010874307,"citer_contribution":3.5579379365387296,"corpus_percentile":null,"corpus_rank":null,"citation_count":155,"citer_count":152,"citers_with_citation_signal":133,"citers_with_endowment":133,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":209742,"name":"Yanfang Li","orcid":null,"position":1,"is_corresponding":false},{"id":241297,"name":"Huaxi Xu","orcid":"0000-0001-7031-7853","position":2,"is_corresponding":false},{"id":1516576,"name":"Yun-wu Zhang","orcid":null,"position":3,"is_corresponding":false},{"id":266542,"name":"Xian Zhang","orcid":"0000-0002-6055-0130","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The γ-secretase complex: from structure to function.","abstract":"One of the most critical pathological features of Alzheimer's disease (AD) is the accumulation of β-amyloid (Aβ) peptides that form extracellular senile plaques in the brain. Aβ is derived from β-amyloid precursor protein (APP) through sequential cleavage by β- and γ-secretases. γ-secretase is a high molecular weight complex minimally composed of four components: presenilins (PS), nicastrin, anterior pharynx defective 1 (APH-1), and presenilin enhancer 2 (PEN-2). In addition to APP, γ-secretase also cleaves many other type I transmembrane (TM) protein substrates. As a crucial enzyme for Aβ production, γ-secretase is an appealing therapeutic target for AD. Here, we summarize current knowledge on the structure and function of γ-secretase, as well as recent progress in developing γ-secretase targeting drugs for AD treatment.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25565961","pmcid":"PMC4263104","openalex_id":null,"authors":[],"funders":[{"funder_name":"NIA NIH HHS","grant_id":"R01 AG021173","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01 AG038710","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"R01 NS046673","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01 AG044420","title":null}],"total_grants":4,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.frontiersin.org/articles/10.3389/fncel.2014.00427/pdf","host_type":"publisher"},{"url":"https://doaj.org/article/4a0d77446a0f43aab11b359bb8c523a1","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4263104","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC4263104","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC4263104?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":[],"mesh_terms":[],"keywords":["Presenilin","Alzheimer’s disease","nicastrin","Γ-secretase","Presenilin Enhancer 2","Anterior Pharynx Defective 1"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-26T14:37:14.421854Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}