{"doi":"10.3389/fnbeh.2025.1603564","title":"Sex-dependent effects of food-restriction on cocaine self-administration and cocaine-seeking in rats","abstract":"Introduction: Misuse of drugs and natural rewards, such as food, share common neural pathways and comparably influence behavioral consequences. Food-restriction enhances drug-taking and drug-seeking behaviors in animals, but the effect of food-restriction on cocaine self-administration and cocaine-seeking in both sexes has not been well characterized. Methods: feeding male and female Wistar rats on the acquisition of cocaine self-administration and cue-induced reinstatement of cocaine-seeking. Results: Food access sex-dependently altered the acquisition of cocaine self-administration such that food-restricted females, but not males, displayed an escalated intake behavior over time. Only food-restricted females differed significantly between active and inactive lever pressing during the reinstatement of cocaine-seeking session. Discussion: Taken together, these results suggest that food-restriction sex-dependently improves learning of cocaine self-administration that persists to alter cocaine-seeking behavior following abstinence.","journal":"Frontiers in Behavioral Neuroscience","year":2025,"id":544722,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9558,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1435637,"name":"Ava M. Mac","orcid":null,"position":1,"is_corresponding":false},{"id":665148,"name":"Srinivasu Kallakuri","orcid":"0000-0002-4681-6350","position":2,"is_corresponding":false},{"id":454936,"name":"Mark K. Greenwald","orcid":"0000-0002-9541-7321","position":3,"is_corresponding":false},{"id":492421,"name":"Shane A. Perrine","orcid":"0000-0001-6983-2372","position":4,"is_corresponding":false},{"id":1078137,"name":"Alixandria T. Mascarin","orcid":null,"position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":null,"created_at":"2026-07-19T02:53:17.418915Z","pmid":"40556835","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}