{"doi":"10.3389/fnagi.2025.1599402","title":"α-klotho as a biomarker of amyloid β levels in the cerebrospinal fluid","abstract":"Introduction CSF α -klotho levels might affect Aβ40, Aβ42, and the Aβ42/40 ratio in the cerebrospinal fluid (CSF). Methods CSF α -klotho was assayed in ovariectomized rhesus macaques (NHPs) maintained on a Western-style diet (WSD) to assess the effect of estrogen hormone therapy (HT). CSF and serum α -klotho was also analyzed in females and males of different ages and whether it was associated with Aβ42, Aβ40, or the Aβ42/40 ratio. Furthermore, CSF and serum α -klotho were analyzed in women and men with dementia and controls and whether they were associated with CSF Aβ levels. Results HT was associated with increased CSF α -klotho levels. Furthermore, α -klotho and Aβ levels were correlated in a species- and cognitive health-dependent fashion. Higher CSF and serum levels of α -klotho were seen in controls than in patients with dementia. Discussion Understanding the species differences in the beneficial effects of α -klotho on CSF Aβ physiology should open new avenues for treating AD.","journal":"Frontiers in Aging Neuroscience","year":2025,"id":528379,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9611,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1405844,"name":"Alexandra Pederson","orcid":null,"position":1,"is_corresponding":false},{"id":1406324,"name":"Emily Bunnell","orcid":"0009-0000-4907-7306","position":2,"is_corresponding":false},{"id":325849,"name":"Nora Mattek","orcid":"0000-0003-2623-1969","position":3,"is_corresponding":false},{"id":321222,"name":"Nora E. Gray","orcid":"0000-0001-6848-859X","position":4,"is_corresponding":false},{"id":427479,"name":"Steven G. Kohama","orcid":null,"position":5,"is_corresponding":false},{"id":301291,"name":"Alison R. Weiss","orcid":"0000-0002-1821-8193","position":6,"is_corresponding":false},{"id":226068,"name":"Joseph F. Quinn","orcid":"0000-0001-7305-2256","position":7,"is_corresponding":false},{"id":393623,"name":"Henryk F. Urbanski","orcid":null,"position":8,"is_corresponding":false},{"id":228247,"name":"Jacob Raber","orcid":"0000-0002-9861-9893","position":0,"is_corresponding":true}],"reference_count":36,"raw_metadata":null,"created_at":"2026-07-19T02:50:48.492873Z","pmid":"40625374","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}