{"doi":"10.3389/fnagi.2015.00081","title":"Fractional anisotropy shows differential reduction in frontal-subcortical fiber bundles—A longitudinal MRI study of 76 middle-aged and older adults","abstract":null,"journal":"Frontiers in Aging Neuroscience","year":2015,"id":635443,"datarank":0.4566783656585135,"base_score":3.044522437723423,"endowment":3.044522437723423,"self_citation_contribution":0.4566783656585135,"citation_network_contribution":0.0,"self_endowment_contribution":0.4566783656585135,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1648606,"name":"Erlend Hodneland","orcid":null,"position":1,"is_corresponding":false},{"id":1648608,"name":"Judit Haász","orcid":null,"position":2,"is_corresponding":false},{"id":1648609,"name":"Martin Ystad","orcid":null,"position":3,"is_corresponding":false},{"id":277314,"name":"Astri J. Lundervold","orcid":"0000-0002-6819-6164","position":4,"is_corresponding":false},{"id":683885,"name":"Arvid Lundervold","orcid":"0000-0002-0032-4182","position":5,"is_corresponding":false},{"id":645707,"name":"Alexandra Vik","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Fractional anisotropy shows differential reduction in frontal-subcortical fiber bundles—A longitudinal MRI study of 76 middle-aged and older adults","abstract":"Motivated by the frontal- and white matter (WM) retrogenesis hypotheses and the assumptions that fronto-striatal circuits are especially vulnerable in normal aging, the goal of the present study was to identify fiber bundles connecting subcortical nuclei and frontal areas and obtain site-specific information about age related fractional anisotropy (FA) changes. Multimodal magnetic resonance image acquisitions [3D T1-weighted and diffusion weighted imaging (DWI)] were obtained from healthy older adults (N = 76, range 49-80 years at inclusion) at two time points, 3 years apart. A subset of the participants (N = 24) was included at a third time-point. In addition to the frontal-subcortical fibers, the anterior callosal fiber (ACF) and the corticospinal tract (CST) was investigated by its mean FA together with tract parameterization analysis. Our results demonstrated fronto-striatal structural connectivity decline (reduced FA) in normal aging with substantial inter-individual differences. The tract parameterization analysis showed that the along tract FA profiles were characterized by piece-wise differential changes along their extension rather than being uniformly affected. To the best of our knowledge, this is the first longitudinal study detecting age-related changes in frontal-subcortical WM connections in normal aging.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26029102","pmcid":"PMC4432666","openalex_id":null,"authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.frontiersin.org/articles/10.3389/fnagi.2015.00081/pdf","host_type":"publisher"},{"url":"http://hdl.handle.net/1956/10862","host_type":"repository"},{"url":"https://doaj.org/article/b7ab1a1e063a4fd08de4da8102a6d96c","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4432666","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC4432666","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC4432666?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":[],"mesh_terms":[],"keywords":["Longitudinal study","Diffusion weighted imaging","Tractography","Healthy Aging","Fractional Anisotropy","3D Mri","Tract Parametrization","Frontal-subcortical Fibers"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T15:06:57.325854Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}