{"doi":"10.3389/fmolb.2022.1015990","title":"Editorial: Volume II: Structural and functional characterization of circular RNAs","abstract":"Circular RNAs (circRNAs) are endogenously expressed covalently circularized RNA structures formed via non-canonical backsplicing of the primary transcript where the downstream donor site is ligated to the upstream acceptor site Discovered more than 4 decades ago as \"tiny circles\" in plant viroids and later in eukaryotic cells, circRNAs were initially thought to be junk splicing byproducts However, later on, the identification and functional characterization of circRNAs gained momentum upon the advancements of transcriptome-wide RNA-sequencing technologies and novel circRNA annotation tools Over the years, circRNAs have emerged as one of the most extensively studied RNA species across the eukaryotic tree of life. The unique chimeric closed loop form of circRNAs confers them with certain special properties such as enhanced tolerance to exonuclease attack rendering them stable compared to their linear isoforms An ever-expanding body of research revealed that several circRNAs are conserved across species showing a nearly ubiquitous spatial-and temporal-expression pattern in myriads of mammalian cells and tissue types Increasing evidence suggests that circRNAs can function as regulatory transcripts, which serve as microRNA and RNAbinding protein sponges, and directly act as translation templates","journal":"Frontiers in Molecular Biosciences","year":2022,"id":301801,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9571,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":249142,"name":"Kotb Abdelmohsen","orcid":"0000-0001-6240-5810","position":1,"is_corresponding":false},{"id":275714,"name":"Amaresh C. Panda","orcid":"0000-0003-3189-8995","position":2,"is_corresponding":false},{"id":993271,"name":"Tanvi Sinha","orcid":"0000-0001-9221-6965","position":0,"is_corresponding":true}],"reference_count":16,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:32:06.309890Z","pmid":"36148007","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}