{"doi":"10.3389/fmicb.2024.1423044","title":"An effective pan-serotype dengue vaccine and enhanced control strategies could help in reducing the severe dengue burden in Bangladesh–A perspective","abstract":"<jats:p>Dengue is an important vector-borne disease occurring globally. Dengue virus (DENV) infection can result in a potentially life-threatening disease. To date, no DENV-specific antiviral treatment is available. Moreover, an equally effective pan-serotype dengue virus vaccine is not available. Recently, two DENV vaccines, Dengvaxia and Qdenga, were licensed for limited use. However, none of them have been approved in Bangladesh. DENV is transmitted by <jats:italic>Aedes</jats:italic> mosquitoes, and global warming caused by climate change favoring <jats:italic>Aedes</jats:italic> breeding plays an important role in increasing DENV infections in Bangladesh. Dengue is a serious public health concern in Bangladesh. In the year 2023, Bangladesh witnessed its largest dengue outbreak, with the highest number of dengue cases (<jats:italic>n</jats:italic> = 321,179) and dengue-related deaths (<jats:italic>n</jats:italic> = 1,705) in a single epidemic year. There is an increased risk of severe dengue in individuals with preexisting DENV-specific immunoglobulin G if the individuals become infected with different DENV serotypes. To date, vector control has remained the mainstay for controlling dengue; therefore, an immediate, strengthened, and effective vector control program is critical and should be regularly performed for controlling dengue outbreaks in Bangladesh. In addition, the use of DENV vaccine in curbing dengue epidemics in Bangladesh requires more consideration and judgment by the respective authority of Bangladesh. This review provides perspectives on the control and prevention of dengue outbreaks. We also discuss the challenges of DENV vaccine use to reduce dengue epidemics infection in Bangladesh.</jats:p>","journal":"Frontiers in Microbiology","year":2024,"id":631118,"datarank":0.38474240361923057,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.0,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1635420,"name":"Humayra Nazneen","orcid":null,"position":1,"is_corresponding":false},{"id":138362,"name":"Michinori Kohara","orcid":null,"position":2,"is_corresponding":false},{"id":138361,"name":"Kyoko Tsukiyama-Kohara","orcid":null,"position":3,"is_corresponding":false},{"id":1635419,"name":"Mohammad Enamul Hoque Kayesh","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"An effective pan-serotype dengue vaccine and enhanced control strategies could help in reducing the severe dengue burden in Bangladesh–A perspective","abstract":"<jats:p>Dengue is an important vector-borne disease occurring globally. Dengue virus (DENV) infection can result in a potentially life-threatening disease. To date, no DENV-specific antiviral treatment is available. Moreover, an equally effective pan-serotype dengue virus vaccine is not available. Recently, two DENV vaccines, Dengvaxia and Qdenga, were licensed for limited use. However, none of them have been approved in Bangladesh. DENV is transmitted by <jats:italic>Aedes</jats:italic> mosquitoes, and global warming caused by climate change favoring <jats:italic>Aedes</jats:italic> breeding plays an important role in increasing DENV infections in Bangladesh. Dengue is a serious public health concern in Bangladesh. In the year 2023, Bangladesh witnessed its largest dengue outbreak, with the highest number of dengue cases (<jats:italic>n</jats:italic> = 321,179) and dengue-related deaths (<jats:italic>n</jats:italic> = 1,705) in a single epidemic year. There is an increased risk of severe dengue in individuals with preexisting DENV-specific immunoglobulin G if the individuals become infected with different DENV serotypes. To date, vector control has remained the mainstay for controlling dengue; therefore, an immediate, strengthened, and effective vector control program is critical and should be regularly performed for controlling dengue outbreaks in Bangladesh. In addition, the use of DENV vaccine in curbing dengue epidemics in Bangladesh requires more consideration and judgment by the respective authority of Bangladesh. This review provides perspectives on the control and prevention of dengue outbreaks. We also discuss the challenges of DENV vaccine use to reduce dengue epidemics infection in Bangladesh.</jats:p>","is_dataset_classified":null,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39228383","pmcid":"PMC11368799","openalex_id":"https://openalex.org/W4401977392","authors":[],"funders":[{"funder_name":"Japan Agency for Medical Research and Development","grant_id":"","title":null}],"total_grants":1,"fwci":5.0046,"citation_percentile":0.95866195,"influential_citations":0,"citation_trend":[{"year":2025,"count":8},{"year":2026,"count":4}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1423044/pdf","host_type":"journal"},{"url":"https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1423044/pdf","host_type":"publisher"},{"url":"https://www.frontiersin.org/articles/10.3389/fmicb.2024.1423044/full","host_type":"publisher"},{"url":"https://doi.org/10.3389/fmicb.2024.1423044","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39228383","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11368799","host_type":"repository"},{"url":"https://doaj.org/article/7bf634ce195f415787162bda93f3cb9a","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11368799/pdf/fmicb-15-1423044.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC11368799","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC11368799?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Mosquito-borne diseases and control","Viral Infections and Vectors","Malaria Research and Control"],"mesh_terms":[],"keywords":["Dengue fever","Dengue vaccine","Serotype","Dengue virus","Virology","Perspective (graphical)","Environmental health","Biology","Medicine","Computer science","epidemic","Bangladesh","Severe Dengue Fever","Dengue Virus Vaccine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"nct"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T22:52:03.512324Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}