{"doi":"10.3389/fmicb.2023.1269869","title":"Lactic acid bacterial surface display of scytovirin inhibitors for anti-ebolavirus infection","abstract":"Scytovirin (SVN) is a lectin from cyanobacteria which has a strong inhibitory activity against Ebola virus infection. We engineered scytovirin as the inhibitor for surface display of lactic acid bacteria to block Ebola virus infection. Two different bacterial strains ( Lactobacillus casei and Lactococcus lactis ) were successfully engineered for scytovirin expression on the bacterial surface. These bacteria were found to be effective at neutralizing pseudotyped Ebolavirus in a cell-based assay. This approach can be utilized for prophylactic prevention, as well as for treatment. Since lactic acid bacteria can colonize the human body, a long-term efficacy could be achieved. Furthermore, this approach is also simple and cost-effective and can be easily applied in the regions of Ebola outbreaks in the developing countries.","journal":"Frontiers in Microbiology","year":2023,"id":373859,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9515,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":485416,"name":"Ngan Nguyen","orcid":"0000-0003-0054-801X","position":1,"is_corresponding":false},{"id":1135514,"name":"Wenzhong Wei","orcid":null,"position":2,"is_corresponding":false},{"id":779794,"name":"Leah Liu Wang","orcid":null,"position":3,"is_corresponding":false},{"id":1135515,"name":"Haley Hollingsead Olson","orcid":null,"position":4,"is_corresponding":false},{"id":494194,"name":"Shi-Hua Xiang","orcid":"0000-0002-5656-5698","position":5,"is_corresponding":false},{"id":929955,"name":"Joshua Wiggins","orcid":"0000-0002-8574-5073","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-19T01:16:07.080027Z","pmid":"38075878","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}