{"doi":"10.3389/fmicb.2023.1181034","title":"Lipid A structural diversity among members of the genus Leptospira","abstract":"Lipid A is the hydrophobic component of bacterial lipopolysaccharide and an activator of the host immune system. Bacteria modify their lipid A structure to adapt to the surrounding environment and, in some cases, to evade recognition by host immune cells. In this study, lipid A structural diversity within the Leptospira genus was explored. The individual Leptospira species have dramatically different pathogenic potential that ranges from non-infectious to life-threatening disease (leptospirosis). Ten distinct lipid A profiles, denoted L1-L10, were discovered across 31 Leptospira reference species, laying a foundation for lipid A-based molecular typing. Tandem MS analysis revealed structural features of Leptospira membrane lipids that might alter recognition of its lipid A by the host innate immune receptors. Results of this study will aid development of strategies to improve diagnosis and surveillance of leptospirosis, as well as guide functional studies on Leptospira lipid A activity.","journal":"Frontiers in Microbiology","year":2023,"id":342723,"datarank":0.5353569208938882,"base_score":2.70805020110221,"endowment":2.70805020110221,"self_citation_contribution":0.40620753016533157,"citation_network_contribution":0.1291493907285567,"self_endowment_contribution":0.40620753016533157,"citer_contribution":0.1291493907285567,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":8,"citers_with_citation_signal":7,"citers_with_endowment":7,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9469,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1079696,"name":"Abanoub Mikhael","orcid":"0009-0001-3731-683X","position":1,"is_corresponding":false},{"id":1080259,"name":"Sophie Culos","orcid":null,"position":2,"is_corresponding":false},{"id":1079697,"name":"Alexandre Giraud-Gatineau","orcid":"0000-0003-0984-5977","position":3,"is_corresponding":false},{"id":1080260,"name":"Alloysius M. Gomez","orcid":null,"position":4,"is_corresponding":false},{"id":943274,"name":"Matthew E. Sherman","orcid":"0000-0003-4918-6179","position":5,"is_corresponding":false},{"id":301698,"name":"Robert K. Ernst","orcid":"0000-0001-5016-8694","position":6,"is_corresponding":false},{"id":463851,"name":"Caroline E. Cameron","orcid":"0000-0002-8786-4359","position":7,"is_corresponding":false},{"id":339044,"name":"Mathieu Picardeau","orcid":"0000-0002-5338-5579","position":8,"is_corresponding":false},{"id":267538,"name":"David R. Goodlett","orcid":"0000-0002-8045-8200","position":9,"is_corresponding":false},{"id":768663,"name":"Helena Pětrošová","orcid":null,"position":0,"is_corresponding":true}],"reference_count":81,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:11:17.288563Z","pmid":"37303810","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}