{"doi":"10.3389/fmicb.2022.943379","title":"Editorial: Influence of Protein-Protein Interactions (PPIs) on the Outcome of Viral Infections","abstract":"socio-economical behavior have increased the risk of spillover events and of (re)emergence of zoonotic viruses 14 [1][2][3][4]. It is therefore imperative to establish preventive and therapeutic measures, as well as epidemiological 15 surveillance to mitigate the effect of future outbreaks [5,6].Viruses are genetic parasites that exploit the host's molecular machinery by employing specific virus-17 host protein-protein interactions (PPIs) that mediate critical steps in virus replication and immune evasion.Thus, PPIs are prime targets for the development of therapeutics and vaccines. However, their characterization 19 is an urgent albeit challenging task that benefits drastically from the integration of computational and PARP1 interaction with several viral proteins supports establishment of viral latency by down-regulating viral 29 DNA replication, and reducing virus production to prevent reactivation. Simultaneously, these viruses also 30 employ multiple mechanisms to down-regulate PARP1 expression to then promote their own replication.","journal":"Frontiers in Microbiology","year":2022,"id":300273,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9672,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":990726,"name":"Mercè Llabrés","orcid":"0000-0002-5358-6768","position":1,"is_corresponding":false},{"id":292085,"name":"Pablo Guardado‐Calvo","orcid":"0000-0001-7292-5270","position":2,"is_corresponding":false},{"id":443121,"name":"Eva Mittler","orcid":"0000-0002-5935-6314","position":3,"is_corresponding":false},{"id":240439,"name":"Gorka Lasso","orcid":"0000-0001-5355-323X","position":4,"is_corresponding":false},{"id":109529,"name":"Rohit K. Jangra","orcid":"0000-0002-3119-0869","position":0,"is_corresponding":true}],"reference_count":19,"raw_metadata":null,"created_at":"2026-07-19T00:31:53.559757Z","pmid":"35832810","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}