{"doi":"10.3389/fmicb.2022.1034537","title":"Immune mechanism of gut microbiota and its metabolites in the occurrence and development of cardiovascular diseases","abstract":"<jats:p>The risk of cardiovascular disease (CVD) is associated with unusual changes in the human gut microbiota, most commonly coronary atherosclerotic heart disease, hypertension, and heart failure. Immune mechanisms maintain a dynamic balance between the gut microbiota and the host immune system. When one side changes and the balance is disrupted, different degrees of damage are inflicted on the host and a diseased state gradually develops over time. This review summarizes the immune mechanism of the gut microbiota and its metabolites in the occurrence of common CVDs, discusses the relationship between gut-heart axis dysfunction and the progression of CVD, and lists the currently effective methods of regulating the gut microbiota for the treatment of CVDs.</jats:p>","journal":"Frontiers in Microbiology","year":2022,"id":630482,"datarank":0.519860385419959,"base_score":3.4657359027997265,"endowment":3.4657359027997265,"self_citation_contribution":0.519860385419959,"citation_network_contribution":0.0,"self_endowment_contribution":0.519860385419959,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":31,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":799230,"name":"Xiao Jin","orcid":"0000-0002-5423-0982","position":1,"is_corresponding":false},{"id":1391865,"name":"Shengjie Yang","orcid":"0000-0001-6398-317X","position":2,"is_corresponding":false},{"id":1633357,"name":"Yujuan Li","orcid":null,"position":3,"is_corresponding":false},{"id":821483,"name":"Xinyue Wang","orcid":"0000-0001-9793-8211","position":4,"is_corresponding":false},{"id":257445,"name":"Min Wu","orcid":"0000-0003-1205-982X","position":5,"is_corresponding":false},{"id":1360422,"name":"Jing Lu","orcid":"0009-0007-7144-1398","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Immune mechanism of gut microbiota and its metabolites in the occurrence and development of cardiovascular diseases","abstract":"<jats:p>The risk of cardiovascular disease (CVD) is associated with unusual changes in the human gut microbiota, most commonly coronary atherosclerotic heart disease, hypertension, and heart failure. Immune mechanisms maintain a dynamic balance between the gut microbiota and the host immune system. When one side changes and the balance is disrupted, different degrees of damage are inflicted on the host and a diseased state gradually develops over time. This review summarizes the immune mechanism of the gut microbiota and its metabolites in the occurrence of common CVDs, discusses the relationship between gut-heart axis dysfunction and the progression of CVD, and lists the currently effective methods of regulating the gut microbiota for the treatment of CVDs.</jats:p>","is_dataset_classified":null,"base_score":3.4657359027997265,"endowment":3.4657359027997265,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36590426","pmcid":"PMC9794627","openalex_id":"https://openalex.org/W4311330120","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"","title":null}],"total_grants":1,"fwci":2.1154,"citation_percentile":0.88432617,"influential_citations":0,"citation_trend":[{"year":2023,"count":5},{"year":2024,"count":12},{"year":2025,"count":10},{"year":2026,"count":4}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.frontiersin.org/articles/10.3389/fmicb.2022.1034537/pdf","host_type":"journal"},{"url":"https://www.frontiersin.org/articles/10.3389/fmicb.2022.1034537/pdf","host_type":"publisher"},{"url":"https://www.frontiersin.org/articles/10.3389/fmicb.2022.1034537/full","host_type":"publisher"},{"url":"https://doi.org/10.3389/fmicb.2022.1034537","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36590426","host_type":"repository"},{"url":"https://doaj.org/article/3e40c1be0f714bfc8c9172962bf659ed","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9794627","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC9794627","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC9794627?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Gut microbiota and health","Clostridium difficile and Clostridium perfringens research","Tryptophan and brain disorders"],"mesh_terms":[],"keywords":["Gut flora","Immune system","Mechanism (biology)","Gut–brain axis","Gut bacteria","Disease","Immunology","Biology","Host (biology)","Inflammation","Medicine","Internal medicine","Ecology","Metabolites","Cardiovascular diseases","Immune mechanism","Intestinal Microbiota","Gut Microbiota Regulation"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T21:25:54.786312Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}