{"doi":"10.3389/fmicb.2020.596851","title":"Prevalence of Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Antibodies in Egyptian Convalescent Plasma Donors","abstract":"Using convalescent plasma as immunotherapy is an old method for treatment of infectious diseases. Several countries have recently allowed the use of such therapy for the treatment of COVID-19 patients especially those who are critically ill. A similar program is currently being tested in Egypt. Here, we tested 227 plasma samples from convalescent donors in Egypt for neutralizing antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using a microneutralization (MN) assay. A third of the tested samples did not have antibody titers and 58% had titers between 1:10 and 1:80. Only 12% had titers >1:160. We also compared MN assays using different virus concentrations, plaque reduction neutralization (PRNT) assays, and a chemiluminescence assay that measures immunoglobulin G (IgG) binding to N and S proteins of SARS-CoV-2. Our results indicated that a MN assay using 100 TCID50/ml provides comparable results to PRNT and allows for high throughput testing.","journal":"Frontiers in Microbiology","year":2020,"id":106869,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9592,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":348308,"name":"Ahmed Kandeil","orcid":"0000-0003-3253-6961","position":1,"is_corresponding":false},{"id":349578,"name":"Ahmed Mostafa","orcid":null,"position":2,"is_corresponding":false},{"id":350546,"name":"Wael H. Roshdy","orcid":"0000-0001-8412-3128","position":3,"is_corresponding":false},{"id":424660,"name":"Ahmed E. Kayed","orcid":"0000-0002-0439-3476","position":4,"is_corresponding":false},{"id":348309,"name":"Mahmoud Shehata","orcid":"0000-0001-7556-9398","position":5,"is_corresponding":false},{"id":350548,"name":"Omnia Kutkat","orcid":"0000-0003-2256-2816","position":6,"is_corresponding":false},{"id":350547,"name":"Yassmin Moatasim","orcid":"0000-0003-2159-2511","position":7,"is_corresponding":false},{"id":425465,"name":"Ahmed El Taweel","orcid":null,"position":8,"is_corresponding":false},{"id":424661,"name":"Sara H. Mahmoud","orcid":"0000-0002-1011-5608","position":9,"is_corresponding":false},{"id":424662,"name":"Mina Nabil Kamel","orcid":"0000-0002-9130-3079","position":10,"is_corresponding":false},{"id":352125,"name":"Noura M. Abo Shama","orcid":null,"position":11,"is_corresponding":false},{"id":425466,"name":"Mohamed El Sayes","orcid":null,"position":12,"is_corresponding":false},{"id":348310,"name":"Rabeh El‐Shesheny","orcid":"0000-0002-8798-2240","position":13,"is_corresponding":false},{"id":515582,"name":"Osama Bakheet","orcid":null,"position":14,"is_corresponding":false},{"id":515583,"name":"Mohamed A. Elgohary","orcid":null,"position":15,"is_corresponding":false},{"id":492323,"name":"Mohamed Elbadry","orcid":"0000-0002-9020-8870","position":16,"is_corresponding":false},{"id":515584,"name":"Naguib N. Nassif","orcid":null,"position":17,"is_corresponding":false},{"id":515585,"name":"Salwa H. Ahmed","orcid":null,"position":18,"is_corresponding":false},{"id":515586,"name":"Ibrahim Y. Abdel Messih","orcid":null,"position":19,"is_corresponding":false},{"id":348311,"name":"Ghazi Kayali","orcid":"0000-0002-5387-1622","position":20,"is_corresponding":false},{"id":348312,"name":"Mohamed A. Ali","orcid":"0000-0002-5615-3212","position":21,"is_corresponding":false},{"id":350549,"name":"Mokhtar R. Gomaa","orcid":"0000-0001-7947-3609","position":0,"is_corresponding":true}],"reference_count":17,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:12:31.053776Z","pmid":"33329484","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}