{"doi":"10.3389/fmed.2023.1236702","title":"Longitudinal clinical phenotyping of post COVID condition in Mexican adults recovering from severe COVID-19: a prospective cohort study","abstract":"Introduction: Few studies have evaluated the presence of Post COVID-19 conditions (PCC) in people from Latin America, a region that has been heavily afflicted by the COVID-19 pandemic. In this study, we describe the frequency, co-occurrence, predictors, and duration of 23 symptoms in a cohort of Mexican patients with PCC. Methods: We prospectively enrolled and followed adult patients hospitalized for severe COVID-19 at a tertiary care centre in Mexico City. The incidence of PCC symptoms was determined using questionnaires. Unsupervised clustering of PCC symptom co-occurrence and Kaplan-Meier analyses of symptom persistence were performed. The effect of baseline clinical characteristics was evaluated using Cox regression models and reported with hazard ratios (HR). Results: We found that amongst 192 patients with PCC, respiratory problems were the most prevalent and commonly co-occurred with functional activity impairment. 56% had ≥5 persistent symptoms. Symptom persistence probability at 360 days 0.78. Prior SARS-CoV-2 vaccination and infection during the Delta variant wave were associated with a shorter duration of PCC. Male sex was associated with a shorter duration of functional activity impairment and respiratory symptoms. Hypertension and diabetes were associated with a longer duration of functional impairment. Previous vaccination accelerated PCC recovery. Discussion: In our cohort, PCC symptoms were frequent (particularly respiratory and neurocognitive ones) and persistent. Importantly, prior SARS-CoV-2 vaccination resulted in a shorter duration of PCC.","journal":"Frontiers in Medicine","year":2023,"id":337567,"datarank":0.44166584687496613,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"self_citation_contribution":0.44166584687496613,"citation_network_contribution":0.0,"self_endowment_contribution":0.44166584687496613,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.5786,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":806422,"name":"Joshua Gillard","orcid":"0000-0001-8509-2212","position":1,"is_corresponding":false},{"id":1069367,"name":"Sergio Fragoso-Saavedra","orcid":"0000-0002-4204-9502","position":2,"is_corresponding":false},{"id":628496,"name":"Dorien Feyaerts","orcid":"0000-0002-0795-6625","position":3,"is_corresponding":false},{"id":1070005,"name":"León Islas-Weinstein","orcid":null,"position":4,"is_corresponding":false},{"id":1070006,"name":"Angel A. Gallegos-Guzmán","orcid":null,"position":5,"is_corresponding":false},{"id":1070007,"name":"Uriel Valente-García","orcid":null,"position":6,"is_corresponding":false},{"id":642233,"name":"Justin Meyerowitz","orcid":"0000-0001-7194-8286","position":7,"is_corresponding":false},{"id":868603,"name":"J. Daniel Kelly","orcid":"0009-0001-8410-6069","position":8,"is_corresponding":false},{"id":238075,"name":"Han Chen","orcid":"0000-0002-1722-8736","position":9,"is_corresponding":false},{"id":278121,"name":"Edward A. Ganio","orcid":"0000-0002-1088-0377","position":10,"is_corresponding":false},{"id":1018068,"name":"Alexander Benkendorff","orcid":"0000-0002-5473-2990","position":11,"is_corresponding":false},{"id":1069368,"name":"Jaime Flores‐Gouyonnet","orcid":"0009-0001-8520-463X","position":12,"is_corresponding":false},{"id":1070008,"name":"Pedro Dammann-Beltrán","orcid":null,"position":13,"is_corresponding":false},{"id":1070009,"name":"José Francisco Heredia-González","orcid":null,"position":14,"is_corresponding":false},{"id":1070010,"name":"Gabriela A. Rangel-Gutiérrez","orcid":null,"position":15,"is_corresponding":false},{"id":52017,"name":"Catherine A. Blish","orcid":"0000-0001-6946-7627","position":16,"is_corresponding":false},{"id":36438,"name":"Kari C. Nadeau","orcid":"0000-0002-2146-2955","position":17,"is_corresponding":false},{"id":35731,"name":"Garry P. Nolan","orcid":"0000-0002-8862-9043","position":18,"is_corresponding":false},{"id":339078,"name":"José C. Crispín","orcid":"0000-0002-7590-3621","position":19,"is_corresponding":false},{"id":107287,"name":"David R. McIlwain","orcid":"0000-0002-2537-0273","position":20,"is_corresponding":false},{"id":86469,"name":"Brice Gaudillière","orcid":"0000-0002-3475-5706","position":21,"is_corresponding":false},{"id":744455,"name":"Sergio Iván Valdés‐Ferrer","orcid":"0000-0002-4863-6484","position":22,"is_corresponding":false},{"id":1069366,"name":"Isaac Núñez","orcid":"0000-0001-8859-9115","position":0,"is_corresponding":true}],"reference_count":55,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:10:31.133446Z","pmid":"37727759","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}