{"doi":"10.3389/fmed.2022.972145","title":"Tuberculosis treatment outcomes of diabetic and non-diabetic TB/HIV co-infected patients: A nationwide observational study in Brazil","abstract":"Background: Tuberculosis (TB) is a worldwide public health problem, especially in countries that also report high numbers of people living with HIV (PLWH) and/or diabetes mellitus (DM). However, the unique features of persons with TB-HIV-DM are incompletely understood. This study compared anti-TB treatment (ATT) outcomes of diabetic and non-diabetic TB/HIV co-infected patients. Methods: A nationwide retrospective observational investigation was performed with data from the Brazilian Tuberculosis Database System among patients reported to have TB-HIV co-infection between 2014 and 2019. This database includes all reported TB cases in Brazil. Exploratory and association analyses compared TB treatment outcomes in DM and non-DM patients. Unfavorable outcomes were defined as death, treatment failure, loss to follow-up or recurrence. Multivariable stepwise logistic regressions were used to identify the variables associated with unfavorable ATT outcomes in the TB-HIV population. Results: = 0.781]. Furthermore, DM was also not associated with any specific type of unfavorable outcome in this study. In both the TB-HIV group and the TB-HIV-DM subpopulation, use of alcohol, illicit drugs and tobacco, as well as non-white ethnicity and prior TB were all characteristics more frequently observed in persons who experienced an unfavorable ATT outcome. Conclusion: DM is not associated with unfavorable TB treatment outcomes in persons with TB-HIV, including death, treatment failure, recurrence and loss to follow up. However, consumption habits, non-white ethnicity and prior TB are all more frequently detected in those with unfavorable outcomes in both TB-HIV and TB-HIV-DM patients.","journal":"Frontiers in Medicine","year":2022,"id":286715,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9578,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":517545,"name":"Beatriz Barreto‐Duarte","orcid":"0000-0002-9901-8328","position":1,"is_corresponding":false},{"id":871829,"name":"Vanessa M. Nunes","orcid":null,"position":2,"is_corresponding":false},{"id":482810,"name":"Rodrigo Caldas Menezes","orcid":"0000-0003-1853-3449","position":3,"is_corresponding":false},{"id":706820,"name":"Moreno Magalhães de Souza Rodrigues","orcid":"0000-0002-1594-2311","position":4,"is_corresponding":false},{"id":382615,"name":"Artur T. L. Queiroz","orcid":"0000-0003-4908-9993","position":5,"is_corresponding":false},{"id":341772,"name":"María B. Arriaga","orcid":"0000-0001-6883-8422","position":6,"is_corresponding":false},{"id":689803,"name":"Marcelo Cordeiro‐Santos","orcid":"0000-0002-7140-7145","position":7,"is_corresponding":false},{"id":110663,"name":"Afranio Kritski","orcid":"0000-0002-5900-6007","position":8,"is_corresponding":false},{"id":240257,"name":"Timothy R. Sterling","orcid":"0000-0002-4822-6979","position":9,"is_corresponding":false},{"id":479093,"name":"Mariana Araújo‐Pereira","orcid":"0000-0002-1141-1580","position":10,"is_corresponding":false},{"id":252301,"name":"Bruno B. Andrade","orcid":"0000-0001-6833-3811","position":11,"is_corresponding":false},{"id":871041,"name":"Klauss Villalva-Serra","orcid":"0000-0001-9499-7929","position":0,"is_corresponding":true}],"reference_count":23,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:29:52.825777Z","pmid":"36186793","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}