{"doi":"10.3389/fmed.2022.892146","title":"Intrauterine Hematoma in the First Trimester and Pregnancy Complications: A Systematic Review and Meta-Analysis","abstract":"<jats:sec><jats:title>Background</jats:title><jats:p>Studies evaluating the relationship between intrauterine hematoma in the first trimester and prenatal complications are conflicting.</jats:p></jats:sec><jats:sec><jats:title>Objectives</jats:title><jats:p>To evaluate whether intrauterine hematoma identified in the first trimester in women with singleton pregnancies is associated with adverse perinatal outcomes.</jats:p></jats:sec><jats:sec><jats:title>Search Strategy</jats:title><jats:p>A comprehensive literature search of three databases (Embase, PubMed, and Web of Science) was performed up to September 2021.</jats:p></jats:sec><jats:sec><jats:title>Selection Criteria</jats:title><jats:p>Cohort and case-control studies that have evaluated the relationship between intrauterine hematoma identified before 14 gestational weeks and the risk of prenatal complications, in women with a singleton pregnancy.</jats:p></jats:sec><jats:sec><jats:title>Data Collection and Analysis</jats:title><jats:p>Two members of our team independently assessed the studies for inclusion, collected the data of interest, and assessed the risk of bias, and calculated pooled odds ratios (ORs) using random-effects models.</jats:p></jats:sec><jats:sec><jats:title>Main Results</jats:title><jats:p>Nine studies, including 1,132 women with intrauterine hematoma and 11,179 controls met the inclusion criteria. Intrauterine hematoma increased the risk of spontaneous abortion [OR 2.15, 95% confidence interval (CI) 1.23–3.75], preterm birth (OR 1.83, 95% CI 1.37–2.43), fetal growth restriction (OR 2.33, 95% CI 1.13–4.83) and placental abruption (OR 3.16, 95% CI 1.23–8.13). No statistically significant association was found between intrauterine hematoma and preeclampsia (OR 1.30, 95% CI 0.87–1.94).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Intrauterine hematoma in the first trimester of pregnancy increases the risk of spontaneous abortion, preterm birth, placental abruption, and fetal growth restriction.</jats:p></jats:sec><jats:sec><jats:title>Systematic Review Registration</jats:title><jats:p><jats:ext-link>https://www.crd.york.ac.uk/PROSPERO/</jats:ext-link>.</jats:p></jats:sec>","journal":"Frontiers in Medicine","year":2022,"id":646331,"datarank":0.3596842909197557,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.0,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":164907,"name":"Yu Xu","orcid":"0000-0002-0894-5311","position":1,"is_corresponding":false},{"id":559340,"name":"Yi Du","orcid":"0000-0003-4044-1989","position":2,"is_corresponding":false},{"id":1683384,"name":"Ya-li Chen","orcid":null,"position":3,"is_corresponding":false},{"id":473318,"name":"Liang Sun","orcid":"0000-0002-7817-5121","position":4,"is_corresponding":false},{"id":1683386,"name":"Ai Zheng","orcid":null,"position":5,"is_corresponding":false},{"id":1683381,"name":"Zhao-juan Qin","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Intrauterine Hematoma in the First Trimester and Pregnancy Complications: A Systematic Review and Meta-Analysis","abstract":"Background: Studies evaluating the relationship between intrauterine hematoma in the first trimester and prenatal complications are conflicting. Objectives: To evaluate whether intrauterine hematoma identified in the first trimester in women with singleton pregnancies is associated with adverse perinatal outcomes. Search Strategy: A comprehensive literature search of three databases (Embase, PubMed, and Web of Science) was performed up to September 2021. Selection Criteria: Cohort and case-control studies that have evaluated the relationship between intrauterine hematoma identified before 14 gestational weeks and the risk of prenatal complications, in women with a singleton pregnancy. Data Collection and Analysis: Two members of our team independently assessed the studies for inclusion, collected the data of interest, and assessed the risk of bias, and calculated pooled odds ratios (ORs) using random-effects models. Main Results: Nine studies, including 1,132 women with intrauterine hematoma and 11,179 controls met the inclusion criteria. Intrauterine hematoma increased the risk of spontaneous abortion [OR 2.15, 95% confidence interval (CI) 1.23-3.75], preterm birth (OR 1.83, 95% CI 1.37-2.43), fetal growth restriction (OR 2.33, 95% CI 1.13-4.83) and placental abruption (OR 3.16, 95% CI 1.23-8.13). No statistically significant association was found between intrauterine hematoma and preeclampsia (OR 1.30, 95% CI 0.87-1.94). Conclusion: Intrauterine hematoma in the first trimester of pregnancy increases the risk of spontaneous abortion, preterm birth, placental abruption, and fetal growth restriction. 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