{"doi":"10.3389/fmed.2022.849222","title":"Inpatient Administration of Alpha-1-Adrenergic Receptor Blocking Agents Reduces Mortality in Male COVID-19 Patients","abstract":"Apha-1-adrenergic receptor antagonists (α 1 -blockers) can suppress pro-inflammatory cytokines, thereby potentially improving outcomes among patients with COVID-19. Accordingly, we evaluated the association between α 1 -blocker exposure (before or during hospitalization) and COVID-19 in-hospital mortality. We identified 2,627 men aged 45 or older who were admitted to Mount Sinai hospitals with COVID-19 between February 24 and May 31, 2020, in New York. Men exposed to α 1 -blockers ( N = 436) were older (median age 73 vs. 64 years, P < 0.001) and more likely to have comorbidities than unexposed men ( N = 2,191). Overall, 777 (29.6%) patients died in hospital, and 1,850 (70.4%) were discharged. Notably, we found that α 1 -blocker exposure was independently associated with improved in-hospital mortality in a multivariable logistic analysis (OR 0.699; 95% CI, 0.498-0.982; P = 0.039) after adjusting for patient demographics, comorbidities, and baseline vitals and labs. The protective effect of α 1 -blockers was stronger among patients with documented inpatient exposure to α 1 -blockers (OR 0.624; 95% CI 0.431-0.903; P = 0.012). Finally, age-stratified analyses suggested variable benefit from inpatient α 1 -blocker across age groups: Age 45-65 OR 0.483, 95% CI 0.216-1.081 ( P = 0.077); Age 55-75 OR 0.535, 95% CI 0.323-0.885 ( P = 0.015); Age 65-89 OR 0.727, 95% CI 0.484-1.092 ( P = 0.124). Taken together, clinical trials to assess the therapeutic value of α 1 -blockers for COVID-19 complications are warranted.","journal":"Frontiers in Medicine","year":2022,"id":290852,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9506,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1996,"name":"Tomi Jun","orcid":"0000-0002-2120-1704","position":1,"is_corresponding":false},{"id":289201,"name":"Jonathan Tyler","orcid":"0000-0002-7241-8321","position":2,"is_corresponding":false},{"id":681955,"name":"Emilio Schadt","orcid":"0000-0001-7683-6566","position":3,"is_corresponding":false},{"id":973722,"name":"Yu-Han Kao","orcid":"0000-0003-2416-4395","position":4,"is_corresponding":false},{"id":76157,"name":"Zichen Wang","orcid":"0000-0002-1415-1286","position":5,"is_corresponding":false},{"id":270633,"name":"Maximilian F. Konig","orcid":"0000-0001-5045-5255","position":6,"is_corresponding":false},{"id":24634,"name":"Chetan Bettegowda","orcid":"0000-0001-9991-7123","position":7,"is_corresponding":false},{"id":235162,"name":"Joshua T Vogelstein","orcid":"0000-0003-2487-6237","position":8,"is_corresponding":false},{"id":2254,"name":"Nickolas Papadopoulos","orcid":"0000-0001-7135-7451","position":9,"is_corresponding":false},{"id":4789,"name":"Ramon Parsons","orcid":"0000-0002-6656-3514","position":10,"is_corresponding":false},{"id":50,"name":"Rong Chen","orcid":"0000-0001-6322-0340","position":11,"is_corresponding":false},{"id":5797,"name":"Eric E. Schadt","orcid":"0000-0002-7892-8808","position":12,"is_corresponding":false},{"id":2699,"name":"Li Li","orcid":"0000-0001-6746-4297","position":13,"is_corresponding":false},{"id":501295,"name":"William Oh","orcid":"0000-0001-5113-8147","position":14,"is_corresponding":false},{"id":619041,"name":"Shilong Li","orcid":"0000-0002-9581-8029","position":0,"is_corresponding":true}],"reference_count":22,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:30:34.502076Z","pmid":"35295598","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}